OBJECTS: Diffuse high-grade gliomas are known to develop in children after cranial irradiation for other malignancies. Here, clinicopathological characteristics are outlined. METHODS: Nine children received cranial irradiation and chemotherapy for medulloblastoma (n=2) or acute lymphoblastic leukemia (n=7). They developed a high-grade glioma 7-14 years thereafter. Clinical charts, radiologic findings, and pathologic specimens were reviewed. Archival material was stained immunohistochemically. CONCLUSION: Gliomas evolving as second malignant neoplasms show peculiarities and differ in some aspects from their "spontaneous" counterparts. Most are supratentorial, contrast-enhancing, space-occupying lesions. They are composed mainly of small undifferentiated cells, which are mainly negative for glial fibrillary acidic protein and positive for microtubule associated proteins 2 (MAP2). Epidermal growth factor receptor labeling could not be detected in any of them. Ki67-labeling was usually high, whereas p53- and h-ras p21-staining was variable. The median survival was only 12 months despite intensive treatment.
OBJECTS: Diffuse high-grade gliomas are known to develop in children after cranial irradiation for other malignancies. Here, clinicopathological characteristics are outlined. METHODS: Nine children received cranial irradiation and chemotherapy for medulloblastoma (n=2) or acute lymphoblastic leukemia (n=7). They developed a high-grade glioma 7-14 years thereafter. Clinical charts, radiologic findings, and pathologic specimens were reviewed. Archival material was stained immunohistochemically. CONCLUSION:Gliomas evolving as second malignant neoplasms show peculiarities and differ in some aspects from their "spontaneous" counterparts. Most are supratentorial, contrast-enhancing, space-occupying lesions. They are composed mainly of small undifferentiated cells, which are mainly negative for glial fibrillary acidic protein and positive for microtubule associated proteins 2 (MAP2). Epidermal growth factor receptor labeling could not be detected in any of them. Ki67-labeling was usually high, whereas p53- and h-ras p21-staining was variable. The median survival was only 12 months despite intensive treatment.
Authors: M V Relling; J E Rubnitz; G K Rivera; J M Boyett; M L Hancock; C A Felix; L E Kun; A W Walter; W E Evans; C H Pui Journal: Lancet Date: 1999-07-03 Impact factor: 79.321
Authors: C Kitanaka; N Shitara; T Nakagomi; H Nakamura; S Genka; K Nakagawa; A Akanuma; H Aoyama; K Takakura Journal: J Neurosurg Date: 1989-03 Impact factor: 5.115
Authors: D J Brat; C D James; A E Jedlicka; D C Connolly; E Chang; R J Castellani; M Schmid; M Schiller; D A Carson; P C Burger Journal: Am J Pathol Date: 1999-05 Impact factor: 4.307
Authors: Mehmet Kantar; Nazan Cetingül; Savaş Kansoy; Yavuz Anacak; Eren Demirtaş; Yusuf Erşahin; Saffet Mutluer Journal: Childs Nerv Syst Date: 2003-07-29 Impact factor: 1.475