BACKGROUND: Secondary malignant neoplasms (SMN) in CNS tumor survivors has become problem of increasing concern over the last 20 years. These tumors usually occur in a different site from the primary brain tumor several years after treatment. CASE REPORT: We report secondary cranial malignant neoplasms in three patients who were treated with irradiation and chemotherapy for their primary brain tumors. The first case is a male survivor of an orbital rhabdomyosarcoma who developed a meningioma 8 years later. The other two cases are female survivors of ependymomas who were irradiated at the age of 3 and developed secondary gliomas 8 and 17 years after therapy respectively. CONCLUSION: Patients carry a risk of developing SMNs many years later since irradiation is still an important part of the treatment. An SMN may have a benign course, as in meningioma, or be a dilemma for the patient, as in glioblastoma.
BACKGROUND: Secondary malignant neoplasms (SMN) in CNS tumor survivors has become problem of increasing concern over the last 20 years. These tumors usually occur in a different site from the primary brain tumor several years after treatment. CASE REPORT: We report secondary cranial malignant neoplasms in three patients who were treated with irradiation and chemotherapy for their primary brain tumors. The first case is a male survivor of an orbital rhabdomyosarcoma who developed a meningioma 8 years later. The other two cases are female survivors of ependymomas who were irradiated at the age of 3 and developed secondary gliomas 8 and 17 years after therapy respectively. CONCLUSION:Patients carry a risk of developing SMNs many years later since irradiation is still an important part of the treatment. An SMN may have a benign course, as in meningioma, or be a dilemma for the patient, as in glioblastoma.
Authors: R Heyn; V Haeberlen; W A Newton; A H Ragab; R B Raney; M Tefft; M Wharam; L G Ensign; H M Maurer Journal: J Clin Oncol Date: 1993-02 Impact factor: 44.544
Authors: S Nishio; T Morioka; T Inamura; I Takeshita; M Fukui; M Sasaki; K Nakamura; S Wakisaka Journal: Acta Neurochir (Wien) Date: 1998 Impact factor: 2.216
Authors: N Daniel Berger; Peter M Brownlee; Myra J Chen; Hali Morrison; Katalin Osz; Nicolas P Ploquin; Jennifer A Chan; Aaron A Goodarzi Journal: NAR Cancer Date: 2022-04-12