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Literature DB >> 17020300

A strategy for the total synthesis of dragmacidin E. Construction of the core ring system.

Abstract

[reaction: see text] The construction of the dragmacidin core ring system by a route that features the application of a new indole annelation reaction sequence is described.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17020300 PMCID： PMC2547343 DOI： 10.1021/ol0617547

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

12 in total

Review 1. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

Authors: Adam McCluskey; Alistair T R Sim; Jennette A Sakoff
Journal: J Med Chem Date: 2002-03-14 Impact factor: 7.446

2. The total synthesis of (+)-dragmacidin F.

Authors: Neil K Garg; Daniel D Caspi; Brian M Stoltz
Journal: J Am Chem Soc Date: 2004-08-11 Impact factor: 15.419

3. Dragmacidins: new protein phosphatase inhibitors from a southern australian deep-water marine sponge, spongosorites sp

Authors:
Journal: J Nat Prod Date: 1998-05 Impact factor: 4.050

4. An approach to the total synthesis of welwistatin.

Authors: Thomas J Greshock; Raymond L Funk
Journal: Org Lett Date: 2006-06-08 Impact factor: 6.005

5. The first total synthesis of dragmacidin d.

Authors: Neil K Garg; Richmond Sarpong; Brian M Stoltz
Journal: J Am Chem Soc Date: 2002-11-06 Impact factor: 15.419

6. Development of an enantiodivergent strategy for the total synthesis of (+)- and (-)-dragmacidin f from a single enantiomer of quinic Acid.

Authors: Neil K Garg; Daniel D Caspi; Brian M Stoltz
Journal: J Am Chem Soc Date: 2005-04-27 Impact factor: 15.419

7. Dragmacidin E synthesis studies. Preparation of a model cycloheptannelated indole fragment.

Authors: Ken S Feldman; Paiboon Ngernmeesri
Journal: Org Lett Date: 2005-11-24 Impact factor: 6.005

8. Syntheses and cytotoxicity evaluation of bis(indolyl)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: analogues of cytotoxic marine bis(indole) alkaloid.

Authors: B Jiang; X H Gu
Journal: Bioorg Med Chem Date: 2000-02 Impact factor: 3.641

A strategy for the total synthesis of dragmacidin E. Construction of the core ring system.

Review 1. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

2. The total synthesis of (+)-dragmacidin F.

3. Dragmacidins: new protein phosphatase inhibitors from a southern australian deep-water marine sponge, spongosorites sp

4. An approach to the total synthesis of welwistatin.

5. The first total synthesis of dragmacidin d.

6. Development of an enantiodivergent strategy for the total synthesis of (+)- and (-)-dragmacidin f from a single enantiomer of quinic Acid.

7. Dragmacidin E synthesis studies. Preparation of a model cycloheptannelated indole fragment.

8. Syntheses and cytotoxicity evaluation of bis(indolyl)thiazole, bis(indolyl)pyrazinone and bis(indolyl)pyrazine: analogues of cytotoxic marine bis(indole) alkaloid.

9. Synthesis of marine sponge bisindole alkaloids dihydrohamacanthins.

10. Expanding the substrate scope for C-H amination reactions: oxidative cyclization of urea and guanidine derivatives.

1. Total synthesis of (±)-dragmacidin E.

2. Syntheses of Cyclic Guanidine-Containing Natural Products.

3. Total Synthesis of (±)-Dragmacidin E: Problems Solved and Lessons Learned.

4. Dragmacidin E synthesis studies. Preparation of a model heptacyclic core structure.

Review 5. Garner's aldehyde as a versatile intermediate in the synthesis of enantiopure natural products.

6. Total synthesis of clostrubin.