Literature DB >> 1701731

Calcitonin gene-related peptide staining intensity is reduced in rat lumbar motoneurons after spinal cord transection: a quantitative immunocytochemical study.

L Marlier1, N Rajaofetra, R Peretti-Renucci, P Kachidian, P Poulat, C Feuerstein, A Privat.   

Abstract

The expression of Calcitonin gene-related peptide (CGRP) has been demonstrated in motoneurons of several species. We have investigated in adult rats the influence of transection of the spinal cord on CGRP immunoreactivity of motoneurons located below the section. Quantitative analysis has been performed with computer-assisted image analysis. As early as 48 h after the section, CGRP immunoreactivity is modified, and the reduction is maximal after one month. Then, both the number of immunoreactive cells and the intensity of staining increase until the 5th month. It is concluded that the expression of CGRP is under the influence of supraspinal afferents to the motoneuron.

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Year:  1990        PMID： 1701731     DOI： 10.1007/bf00230836

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  15 in total

1.  Effect of spinal cord transection in the newborn, weanling, and adult rat on the morphology of thoracic motoneurons.

Authors:  J P Cummings; D J Stelzner
Journal:  Exp Neurol       Date:  1988-05       Impact factor: 5.330

2.  Antisera against small neurotransmitter-like molecules.

Authors:  M Geffard; A M Henrich-Rock; J Dulluc; P Seguela
Journal:  Neurochem Int       Date:  1985       Impact factor: 3.921

3.  The cytoarchitectonic organization of the spinal cord in the cat.

Authors:  B REXED
Journal:  J Comp Neurol       Date:  1952-06       Impact factor: 3.215

Review 4.  Critical review on quantitative autoradiography of D1 and D2 dopaminergic receptors in the striatum of the mammalian brain: differential localization and plastic changes after pharmacological manipulation and dopaminergic input disruption.

Authors:  C Feuerstein; R Peretti-Renucci; M Savasta; B Scatton; M Manier; A Dubois; J Thibault; N Mons; M Geffard
Journal:  Anal Cell Pathol       Date:  1989-06       Impact factor: 2.916

5.  Ontogeny of peptide- and amine-containing neurones in motor, sensory, and autonomic regions of rat and human spinal cord, dorsal root ganglia, and rat skin.

Authors:  E Marti; S J Gibson; J M Polak; P Facer; D R Springall; G Van Aswegen; M Aitchison; M Koltzenburg
Journal:  J Comp Neurol       Date:  1987-12-15       Impact factor: 3.215

6.  Distribution of neurons expressing calcitonin gene-related peptide mRNAs in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pig.

Authors:  M Réthelyi; C B Metz; P K Lund
Journal:  Neuroscience       Date:  1989       Impact factor: 3.590

7.  Effect of calcitonin gene-related peptide on contraction of striated muscle in the mouse.

Authors:  K Takami; Y Kawai; S Uchida; M Tohyama; Y Shiotani; H Yoshida; P C Emson; S Girgis; C J Hillyard; I MacIntyre
Journal:  Neurosci Lett       Date:  1985-09-30       Impact factor: 3.046

8.  Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

Authors:  S G Amara; V Jonas; M G Rosenfeld; E S Ong; R M Evans
Journal:  Nature       Date:  1982-07-15       Impact factor: 49.962

9.  Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes.

Authors:  B Fontaine; A Klarsfeld; T Hökfelt; J P Changeux
Journal:  Neurosci Lett       Date:  1986-10-30       Impact factor: 3.046

10.  Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: evidence from combined immunohistochemistry and acetylcholinesterase staining.

Authors:  J M Lundberg; T Hökfelt; M Schultzberg; K Uvnäs-Wallensten; C Köhler; S I Said
Journal:  Neuroscience       Date:  1979       Impact factor: 3.590
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  6 in total

1.  Modifications of serotonin-, substance P- and calcitonin gene-related peptide-like immunoreactivities in the dorsal horn of the spinal cord of arthritic rats: a quantitative immunocytochemical study.

Authors:  L Marlier; P Poulat; N Rajaofetra; A Privat
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

2.  Calcitonin gene-related peptide-like immunoreactivity in motoneuron pools innervating different hind limb muscles in the rat.

Authors:  F Piehl; U Arvidsson; T Hökfelt; S Cullheim
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

Review 3.  Neuropeptide messenger plasticity in the CNS neurons following axotomy.

Authors:  M Palkovits
Journal:  Mol Neurobiol       Date:  1995 Apr-Jun       Impact factor: 5.590

4.  Effects of irradiation on neuropeptide expression in rat salivary gland and spinal cord.

Authors:  S Forsgren; L Franzén; Y Liang; H Gustafsson; R Henriksson
Journal:  Histochem J       Date:  1994-08

5.  Increased calcitonin gene-related peptide- and cholecystokinin-like immunoreactivities in spinal motoneurones after dorsal rhizotomy.

Authors:  H Taquet; J J Plachot; M Pohl; E Collin; J J Benoliel; S Bourgoin; A Mauborgne; J C Meunier; F Cesselin; M Hamon
Journal:  J Neural Transm Gen Sect       Date:  1992

6.  Origin of the calcitonin gene-related peptide-immunoreactive nerve fibers in the rat shoulder joint.

Authors:  A Kobayashi; N Yoshida; Y Tonosaki; S Kikuchi; Y Sugiura
Journal:  Anat Embryol (Berl)       Date:  1995-05
  6 in total

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