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Literature DB >> 1717303

Modifications of serotonin-, substance P- and calcitonin gene-related peptide-like immunoreactivities in the dorsal horn of the spinal cord of arthritic rats: a quantitative immunocytochemical study.

L Marlier¹, P Poulat, N Rajaofetra, A Privat.

Abstract

Adjuvant-induced arthritis has been produced in adult rats in order to study the reorganization of serotonergic innervation in the spinal cord dorsal horn in a model of chronic pain. Immunocytochemical detection of CGRP and substance P was quantified with an image analyzer, and we found a transient increase for both peptides at 1 and 2 months, followed by a decrease to control levels after four months. At variance, quantification of serotonergic immunoreactivity showed a significant increase which persisted throughout the study. The significance of this finding is discussed with comparison of other experimental models involving reorganization of primary afferents to the spinal cord.

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Year: 1991 PMID： 1717303 DOI： 10.1007/bf00231731

Source DB: PubMed Journal: Exp Brain Res ISSN： 0014-4819 Impact factor: 1.972

51 in total

1. Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis.

Authors: J Schoenen; J Van Hees; J Gybels; M de Castro Costa; J J Vanderhaeghen
Journal: Life Sci Date: 1985-04-01 Impact factor: 5.037

2. Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord.

Authors: R L Nahin; J L Hylden; M J Iadarola; R Dubner
Journal: Neurosci Lett Date: 1989-01-30 Impact factor: 3.046

3. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

Authors: T Hökfelt; A Ljungdahl; L Terenius; R Elde; G Nilsson
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

4. Quantitative immunocytochemistry using an image analyzer. I. Hardware evaluation, image processing, and data analysis.

Authors: R R Mize; R N Holdefer; L B Nabors
Journal: J Neurosci Methods Date: 1988-11 Impact factor: 2.390

5. Ultrastructural localization of substance P in neurons of rat spinal cord.

Authors: V M Pickel; D J Reis; S E Leeman
Journal: Brain Res Date: 1977-02-25 Impact factor: 3.252

6. Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine.

Authors: G Jancsó; T Hökfelt; J M Lundberg; E Kiraly; N Halász; G Nilsson; L Terenius; J Rehfeld; H Steinbusch; A Verhofstad; R Elde; S Said; M Brown
Journal: J Neurocytol Date: 1981-12

7. Modification of serotonergic innervation of the rat spinal cord dorsal horn after neonatal capsaicin treatment.

Authors: L Marlier; N Rajaofetra; P Poulat; A Privat
Journal: J Neurosci Res Date: 1990-01 Impact factor: 4.164

8. Repeated low doses of morphine induce a rapid tolerance in arthritic rats but a potentiation of opiate analgesia in normal animals.

Authors: V Kayser; A Neil; G Guilbaud
Journal: Brain Res Date: 1986-09-24 Impact factor: 3.252

9. Ventilatory response to adjuvant arthritis in the rat.

Authors: F C Colpaert; R H van den Hoogen
Journal: Life Sci Date: 1983-02-28 Impact factor: 5.037

10. Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis.

Authors: F C Colpaert; J Donnerer; F Lembeck
Journal: Life Sci Date: 1983-04-18 Impact factor: 5.037

10 in total

1. Activation of locomotion in adult chronic spinal rats is achieved by transplantation of embryonic raphe cells reinnervating a precise lumbar level.

Authors: M G Ribotta; J Provencher; D Feraboli-Lohnherr; S Rossignol; A Privat; D Orsal
Journal: J Neurosci Date: 2000-07-01 Impact factor: 6.167

2. Chapter 9 The dorsal horn and hyperalgesia.

Authors: Karin N Westlund
Journal: Handb Clin Neurol Date: 2006

Review 3. Serotonergic transmission after spinal cord injury.

Authors: Raffaele Nardone; Yvonne Höller; Aljoscha Thomschewski; Peter Höller; Piergiorgio Lochner; Stefan Golaszewski; Francesco Brigo; Eugen Trinka
Journal: J Neural Transm (Vienna) Date: 2014-05-28 Impact factor: 3.575

4. Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation.

Authors: Chad K Otoshi; Wendy M Walwyn; Niranjala J K Tillakaratne; Hui Zhong; Roland R Roy; V Reggie Edgerton
Journal: J Neurotrauma Date: 2009-04 Impact factor: 5.269

5. Cyclophosphamide cystitis as a model of visceral pain in rats: model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 proteins.

Authors: M Lantéri-Minet; K Bon; J de Pommery; J F Michiels; D Menétrey
Journal: Exp Brain Res Date: 1995 Impact factor: 1.972

6. Glutaminase immunoreactivity and enzyme activity is increased in the rat dorsal root ganglion following peripheral inflammation.

Authors: Kenneth E Miller; John C Balbás; Richard L Benton; Travis S Lam; Kristin M Edwards; Richard M Kriebel; Ruben Schechter
Journal: Pain Res Treat Date: 2011-12-20

10. Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization.

Authors: Xiaoyou Shi; Tian-Zhi Guo; Tzuping Wei; Wen-Wu Li; David J Clark; Wade S Kingery
Journal: Pain Date: 2015-10 Impact factor: 7.926