| Literature DB >> 17015966 |
Jung-Bum Lee1, Kyoko Hayashi, Megumi Hirata, Eiko Kuroda, Eiko Suzuki, Yoshihiro Kubo, Toshimitsu Hayashi.
Abstract
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.Entities:
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Year: 2006 PMID： 17015966 DOI： 10.1248/bpb.29.2135
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233