Literature DB >> 17015223

A hundred years of Alzheimer's disease research.

John Hardy1.   

Abstract

On the 100th anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of progress in our understanding of the disease and outlines the many gaps still remaining. The progress toward effective mechanistic therapy is reviewed.

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Year:  2006        PMID: 17015223     DOI: 10.1016/j.neuron.2006.09.016

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  165 in total

1.  Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.

Authors:  Anna Lord; Ola Philipson; Therése Klingstedt; Gunilla Westermark; Per Hammarström; K Peter R Nilsson; Lars N G Nilsson
Journal:  Am J Pathol       Date:  2011-05       Impact factor: 4.307

2.  Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).

Authors:  Paola Giusti-Rodríguez; Jun Gao; Johannes Gräff; Damien Rei; Takahiro Soda; Li-Huei Tsai
Journal:  J Neurosci       Date:  2011-11-02       Impact factor: 6.167

Review 3.  Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Authors:  Kenneth S Kosik; Peter R Rapp; Naftali Raz; Scott A Small; J David Sweatt; Li-Huei Tsai
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-04-20       Impact factor: 6.053

4.  Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease.

Authors:  Hisham Qosa; Alaa H Abuznait; Ronald A Hill; Amal Kaddoumi
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

5.  Single-particle characterization of Aβ oligomers in solution.

Authors:  Erik C Yusko; Panchika Prangkio; David Sept; Ryan C Rollings; Jiali Li; Michael Mayer
Journal:  ACS Nano       Date:  2012-06-21       Impact factor: 15.881

6.  Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.

Authors:  Neha Sehgal; Alok Gupta; Rupanagudi Khader Valli; Shanker Datt Joshi; Jessica T Mills; Edith Hamel; Pankaj Khanna; Subhash Chand Jain; Suman S Thakur; Vijayalakshmi Ravindranath
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

7.  Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation.

Authors:  Yan Hou; Paritosh Ghosh; Ruiqian Wan; Xin Ouyang; Heping Cheng; Mark P Mattson; Aiwu Cheng
Journal:  Neurobiol Aging       Date:  2013-11-13       Impact factor: 4.673

8.  Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.

Authors:  Jason K Clark; Matthew Furgerson; Jonathon D Crystal; Marcus Fechheimer; Ruth Furukawa; John J Wagner
Journal:  Neurobiol Learn Mem       Date:  2015-09-15       Impact factor: 2.877

9.  Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.

Authors:  Diana W Shineman; Aleksandra S Dain; Minkyu L Kim; Virginia M-Y Lee
Journal:  Biochemistry       Date:  2009-05-05       Impact factor: 3.162

10.  Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease.

Authors:  Hirokazu Fukui; Francisca Diaz; Sofia Garcia; Carlos T Moraes
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-21       Impact factor: 11.205

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