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Literature DB >> 17006761

Mini review: immune response to myelin-derived sulfatide and CNS-demyelination.

Ramesh C Halder¹, A Jahng, I Maricic, Vipin Kumar.

Abstract

Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 17006761 DOI： 10.1007/s11064-006-9145-4

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

37 in total

Review 1. Brain-immune connection: immuno-regulatory properties of CNS-resident cells.

Authors: B Becher; A Prat; J P Antel
Journal: Glia Date: 2000-02-15 Impact factor: 7.452

2. CD1b is expressed in multiple sclerosis lesions.

Authors: L Battistini; F R Fischer; C S Raine; C F Brosnan
Journal: J Neuroimmunol Date: 1996-07 Impact factor: 3.478

3. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.

Authors: Jochen Mattner; Kristin L Debord; Nahed Ismail; Randal D Goff; Carlos Cantu; Dapeng Zhou; Pierre Saint-Mezard; Vivien Wang; Ying Gao; Ning Yin; Kasper Hoebe; Olaf Schneewind; David Walker; Bruce Beutler; Luc Teyton; Paul B Savage; Albert Bendelac
Journal: Nature Date: 2005-03-24 Impact factor: 49.962

4. Self glycolipids as T-cell autoantigens.

Authors: A Shamshiev; A Donda; I Carena; L Mori; L Kappos; G De Libero
Journal: Eur J Immunol Date: 1999-05 Impact factor: 5.532

Review 5. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system.

Authors: L Steinman
Journal: Cell Date: 1996-05-03 Impact factor: 41.582

6. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.

Authors: Sawsan Youssef; Olaf Stüve; Juan C Patarroyo; Pedro J Ruiz; Jennifer L Radosevich; Eun Mi Hur; Manuel Bravo; Dennis J Mitchell; Raymond A Sobel; Lawrence Steinman; Scott S Zamvil
Journal: Nature Date: 2002-11-07 Impact factor: 49.962

7. CSF and serum ganglioside antibody patterns in MS.

Authors: A Stevens; M Weller; H Wiethölter
Journal: Acta Neurol Scand Date: 1992-11 Impact factor: 3.209

8. Elevated ganglioside concentration in serum and peripheral blood lymphocytes from multiple sclerosis patients in remission.

Authors: B A Sela; G Konat; H Offner
Journal: J Neurol Sci Date: 1982-04 Impact factor: 3.181

9. Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis.

Authors: Amjad A Ilyas; Zie-Wie Chen; Stuart D Cook
Journal: J Neuroimmunol Date: 2003-06 Impact factor: 3.478

10. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide.

Authors: Alex Jahng; Igor Maricic; Carlos Aguilera; Susanna Cardell; Ramesh C Halder; Vipin Kumar
Journal: J Exp Med Date: 2004-03-29 Impact factor: 14.307

21 in total

1. Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.

Authors: Valeria R Samygina; Alexander N Popov; Aintzane Cabo-Bilbao; Borja Ochoa-Lizarralde; Felipe Goni-de-Cerio; Xiuhong Zhai; Julian G Molotkovsky; Dinshaw J Patel; Rhoderick E Brown; Lucy Malinina
Journal: Structure Date: 2011-11-09 Impact factor: 5.006

Review 2. Different subsets of natural killer T cells may vary in their roles in health and disease.

Authors: Vipin Kumar; Terry L Delovitch
Journal: Immunology Date: 2014-07 Impact factor: 7.397

3. The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.

Authors: Maria Podbielska; Steven B Levery; Edward L Hogan
Journal: Clin Lipidol Date: 2011-04

Mini review: immune response to myelin-derived sulfatide and CNS-demyelination.

Review 1. Brain-immune connection: immuno-regulatory properties of CNS-resident cells.

2. CD1b is expressed in multiple sclerosis lesions.

3. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.

4. Self glycolipids as T-cell autoantigens.

Review 5. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system.

6. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.

7. CSF and serum ganglioside antibody patterns in MS.

8. Elevated ganglioside concentration in serum and peripheral blood lymphocytes from multiple sclerosis patients in remission.

9. Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis.

10. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide.

1. Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.

Review 2. Different subsets of natural killer T cells may vary in their roles in health and disease.

3. The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.

Review 4. Role of sulfatide in normal and pathological cells and tissues.

Review 5. Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

6. Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system.

7. Proteomic strategies in multiple sclerosis and its animal models.

8. Diffusion tensor imaging of mouse brain stem and cervical spinal cord.

9. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells.

10. NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.