Literature DB >> 1481629

CSF and serum ganglioside antibody patterns in MS.

A Stevens1, M Weller, H Wiethölter.   

Abstract

The authors determined CSF and serum IgG and IgM antibodies to seven gangliosides in 48 patients with multiple sclerosis. Differing ganglioside antibody patterns in CSF but not serum allowed to reclassify 93% of MS patients correctly when compared to patients with Guillain-Barré syndrome or neuroborreliosis. This suggest that the antibody patterns are neither random nor alike in inflammatory diseases of the nervous system. CSF ganglioside antibody titres were found to be different for patients with relapsing remitting (RRMS; n = 35) and chronic progressive (CPMS; n = 13) multiple sclerosis. Our study reveals characteristic ganglioside antibody patterns in MS and confirms previous evidence of disturbed immunoregulation in MS.

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Year:  1992        PMID： 1481629     DOI： 10.1111/j.1600-0404.1992.tb05129.x

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  9 in total

1.  Antibodies against gangliosides GM1 of patients with multiple sclerosis alter the response of neurons to synaptic activation.

Authors:  S S Sergeeva; E Zaprianova; O S Sotnikov; D Deleva; A Filchev; B Sultanov
Journal:  Dokl Biol Sci       Date:  2004 Nov-Dec

2.  Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.

Authors:  Jacqueline R Rivas; Sara J Ireland; Rati Chkheidze; William H Rounds; Joseph Lim; Jordan Johnson; Denise M O Ramirez; Ann J Ligocki; Ding Chen; Alyssa A Guzman; Mark Woodhall; Patrick C Wilson; Eric Meffre; Charles White; Benjamin M Greenberg; Patrick Waters; Lindsay G Cowell; Ann M Stowe; Nancy L Monson
Journal:  Acta Neuropathol       Date:  2016-10-11       Impact factor: 17.088

3.  Serum ganglioside patterns in multiple sclerosis.

Authors:  E Zaprianova; D Deleva; P Ilinov; E Sultanov; A Filchev; L Christova; B Sultanov
Journal:  Neurochem Res       Date:  2001-02       Impact factor: 3.996

4.  The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.

Authors:  Maria Podbielska; Steven B Levery; Edward L Hogan
Journal:  Clin Lipidol       Date:  2011-04

Review 5.  Mini review: immune response to myelin-derived sulfatide and CNS-demyelination.

Authors:  Ramesh C Halder; A Jahng; I Maricic; Vipin Kumar
Journal:  Neurochem Res       Date:  2006-09-28       Impact factor: 3.996

6.  Analysis of the effects of antibodies to gangliosides on the electrical activity of Retzius neurons in the leech and on the functional activity of influx sodium current channels.

Authors:  S S Sergeeva; E Zapryanova; O S Sotnikov; D Deleva; A Fil'chev
Journal:  Neurosci Behav Physiol       Date:  2004-07

7.  Ganglioside changes in brain in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat.

Authors:  E Zaprianova; D Deleva; A Filchev
Journal:  Neurochem Res       Date:  1998-11       Impact factor: 3.996

8.  Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity.

Authors:  Dirk M Zajonc; Igor Maricic; Douglass Wu; Ramesh Halder; Keshab Roy; Chi-Huey Wong; Vipin Kumar; Ian A Wilson
Journal:  J Exp Med       Date:  2005-11-28       Impact factor: 14.307

Review 9.  Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis.

Authors:  Judith M Greer
Journal:  Mult Scler Int       Date:  2013-11-07
  9 in total

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