Literature DB >> 22701512

The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.

Maria Podbielska1, Steven B Levery, Edward L Hogan.   

Abstract

A family of neutral glycosphingolipids containing a 3-O-acetyl-sphingosine galactosylceramide (3-SAG) has been characterized. Seven new derivatives of galactosylceramide (GalCer), designated as fast-migrating cerebrosides (FMCs) by TLC retention factor, have been identified. The simplest compounds - FMC-1 and FMC-2 - of this series have been characterized as the 3-SAG containing nonhydroxy and hydroxy fatty acyl, respectively. The next two - FMC-3 and FMC-4 - add 6-O-acetyl-galactose and the most complex glycosphingolipids, FMC-5, -6 and -7, are 2,3,4,6-tetra-O-acetyl-3-SAG. These hydrophobic myelin lipid biomarkers coappear with GalCer during myelinogenesis and disappear along with GalCer in de- or dys-myelinating disorders. Myelin lipid antigens, including FMCs, are keys to myelin biology, opening the possibility of new and novel immune modulatory tools for treatment of autoimmune diseases including multiple sclerosis.

Entities:  

Year:  2011        PMID： 22701512      PMCID： PMC3373471          DOI： 10.2217/clp.11.8

Source DB:  PubMed          Journal:  Clin Lipidol        ISSN： 1758-4302


  207 in total

1.  NKT and T cells: coordinate regulation of NK-like phenotype and cytokine production.

Authors:  Matthew J Loza; Leonid S Metelitsa; Bice Perussia
Journal:  Eur J Immunol       Date:  2002-12       Impact factor: 5.532

Review 2.  NKT cells: what's in a name?

Authors:  Dale I Godfrey; H Robson MacDonald; Mitchell Kronenberg; Mark J Smyth; Luc Van Kaer
Journal:  Nat Rev Immunol       Date:  2004-03       Impact factor: 53.106

3.  Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

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Journal:  Nat Med       Date:  2005-02-27       Impact factor: 53.440

4.  CD1b is expressed in multiple sclerosis lesions.

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Journal:  J Neuroimmunol       Date:  1996-07       Impact factor: 3.478

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Authors:  E Klenk; J P Löhr
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-12

6.  Structural studies on the Shigella-like Escherichia coli O121 O-specific polysaccharide.

Authors:  H Parolis; L A Parolis; G Olivieri
Journal:  Carbohydr Res       Date:  1997-09-26       Impact factor: 2.104

Review 7.  Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis.

Authors:  J M van Noort; J J Bajramovic; A C Plomp; M J van Stipdonk
Journal:  J Neuroimmunol       Date:  2000-06-01       Impact factor: 3.478

Review 8.  Myelin sheaths: glycoproteins involved in their formation, maintenance and degeneration.

Authors:  R H Quarles
Journal:  Cell Mol Life Sci       Date:  2002-11       Impact factor: 9.261

9.  Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis.

Authors:  Maria V Tejada-Simon; Ying C Q Zang; Jian Hong; Victor M Rivera; Jingwu Z Zhang
Journal:  Ann Neurol       Date:  2003-02       Impact factor: 10.422

10.  Presentation of the same glycolipid by different CD1 molecules.

Authors:  A Shamshiev; H-J Gober; A Donda; Z Mazorra; L Mori; G De Libero
Journal:  J Exp Med       Date:  2002-04-15       Impact factor: 14.307
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  9 in total

Review 1.  The role of sphingolipids in psychoactive drug use and addiction.

Authors:  Liubov S Kalinichenko; Erich Gulbins; Johannes Kornhuber; Christian P Müller
Journal:  J Neural Transm (Vienna)       Date:  2018-01-10       Impact factor: 3.575

Review 2.  Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.

Authors:  Maria Podbielska; Hubert Krotkiewski; Edward L Hogan
Journal:  Neurochem Res       Date:  2012-03-27       Impact factor: 3.996

Review 3.  Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD.

Authors:  Ewud Agborbesong; Linda Xiaoyan Li; Lu Li; Xiaogang Li
Journal:  Front Mol Biosci       Date:  2022-06-29

Review 4.  Sphingolipid Players in Multiple Sclerosis: Their Influence on the Initiation and Course of the Disease.

Authors:  Maria Podbielska; Toshio Ariga; Anna Pokryszko-Dragan
Journal:  Int J Mol Sci       Date:  2022-05-10       Impact factor: 6.208

5.  Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis.

Authors:  Agnieszka Morel; Michał Bijak; Marta Niwald; Elżbieta Miller; Joanna Saluk
Journal:  Redox Rep       Date:  2017-05-19       Impact factor: 4.412

Review 6.  Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination.

Authors:  Martin Zirngibl; Peggy Assinck; Anastasia Sizov; Andrew V Caprariello; Jason R Plemel
Journal:  Mol Neurodegener       Date:  2022-05-07       Impact factor: 18.879

7.  Implications of Lymphocyte Anergy to Glycolipids in Multiple Sclerosis (MS): iNKT Cells May Mediate the MS Infectious Trigger.

Authors:  Edward L Hogan; Maria Podbielska; Joan O'Keeffe
Journal:  J Clin Cell Immunol       Date:  2013-06

8.  Myelin recovery in multiple sclerosis: the challenge of remyelination.

Authors:  Maria Podbielska; Naren L Banik; Ewa Kurowska; Edward L Hogan
Journal:  Brain Sci       Date:  2013-08-28

9.  Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometry.

Authors:  Amir Saeid Mohammadi; Nhu T N Phan; John S Fletcher; Andrew G Ewing
Journal:  Anal Bioanal Chem       Date:  2016-08-22       Impact factor: 4.142
  9 in total

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