Literature DB >> 17005432

Therapeutic effects of differentiated bone marrow stromal cell transplantation on rat models of Parkinson's disease.

Min Ye1, Xi-Jin Wang, Yu-Hong Zhang, Guo-Qiang Lu, Liang Liang, Jie-Yi Xu.   

Abstract

This study was to explore curative effect of bone marrow stromal cells (BMSCs) differentiated into nestin-positive cells transplantation on rat Parkinson's disease (PD) model. The PD rats were selected and allocated randomly into three groups. BMSCs with differentiation, BMSCs without differentiation and physiological saline were injected into right striatum of PD rat. The rotation test and immunofluorescence double staining were done. Frequency of rotation was significantly less in differentiated or non-differentiated BMSCs groups than that in normal saline group. Brdu/GFAP- and Brdu/NSE-positive cells appeared except BrdU/TH-positive cells. BMSCs differentiated had better effect than that of BMSCs without differentiated and physiological saline group.

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Year:  2006        PMID： 17005432     DOI： 10.1016/j.parkreldis.2006.07.013

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN： 1353-8020            Impact factor:   4.891


  15 in total

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Review 7.  A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects.

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8.  Cellular immune response to intrastriatally implanted allogeneic bone marrow stromal cells in a rat model of Parkinson's disease.

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9.  Bone marrow-derived mesenchymal stem cell therapy as a candidate disease-modifying strategy in Parkinson's disease and multiple system atrophy.

Authors:  Phil Hyu Lee; Hyun Jung Park
Journal:  J Clin Neurol       Date:  2009-03-31       Impact factor: 3.077

10.  Liver X receptors agonist promotes differentiation of rat bone marrow derived mesenchymal stem cells into dopaminergic neuron-like cells.

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Journal:  Oncotarget       Date:  2017-12-09
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