Literature DB >> 18273710

Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease.

Ting-Hua Wang1, Zhong-Tang Feng, Peng Wei, Hui Li, Zhen-Jiang Shi, Li-Yan Li.   

Abstract

This study determined the effects of pcDNA3-beta-nerve growth factor (NGF) gene-modified bone marrow stromal cells (BMSC) on the rat model of Parkinson's disease (PD). The recombinant plasmid pcDNA3-beta-NGF was transfected into BMSC, and NGF expression and its biological activity in vitro were detected. BMSC modified by the NGF gene were then grafted into the corpus striatum of PD rats, and the rotation behavior was evaluated at 1, 2, 4, and 6 weeks post-transplantation. A significant improvement in rotation behavior was observed in PD rats subjected to cell transplantation, especially in PD rats receiving NGF-modified BMSC. The genetically modified BMSC survived and expressed beta-NGF but did not differentiate into tyrosine hydroxylase-positive cells in vivo. The present findings suggested that genetically modified BMSC could be effective for PD treatment, and the mechanisms might involve the neuroprotective effects of beta-NGF.

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Year:  2008        PMID： 18273710     DOI： 10.1007/s12031-007-9032-8

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  34 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

Review 2.  Clinical practice. Diagnosis and initial management of Parkinson's disease.

Authors:  John G Nutt; G Frederick Wooten
Journal:  N Engl J Med       Date:  2005-09-08       Impact factor: 91.245

3.  Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury.

Authors:  D Lu; Y Li; L Wang; J Chen; A Mahmood; M Chopp
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4.  Adult bone marrow stromal cells differentiate into neural cells in vitro.

Authors:  J Sanchez-Ramos; S Song; F Cardozo-Pelaez; C Hazzi; T Stedeford; A Willing; T B Freeman; S Saporta; W Janssen; N Patel; D R Cooper; P R Sanberg
Journal:  Exp Neurol       Date:  2000-08       Impact factor: 5.330

Review 5.  The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments.

Authors:  R K Schwarting; J P Huston
Journal:  Prog Neurobiol       Date:  1996-10       Impact factor: 11.685

6.  Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease.

Authors:  Min Ye; Xi-Jin Wang; Yu-Hong Zhang; Guo-Qiang Lu; Liang Liang; Jie-Yi Xu; Sheng-Di Chen
Journal:  Brain Res       Date:  2006-12-24       Impact factor: 3.252

7.  Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine.

Authors:  Edel T Kavanagh; John P Loughlin; Kate Reed Herbert; Peter Dockery; Afshin Samali; Karen M Doyle; Adrienne M Gorman
Journal:  Biochem Biophys Res Commun       Date:  2006-10-30       Impact factor: 3.575

8.  Effects of engrafted neural stem cells derived from GFP transgenic mice in Parkinson's diseases rats.

Authors:  Peng Wei; Jia Liu; Hao-Li Zhou; Zhi-Tong Han; Qing-Ying Wu; Jiang-Xia Pang; Su Liu; Ting-Hua Wang
Journal:  Neurosci Lett       Date:  2007-03-25       Impact factor: 3.046

9.  Bone marrow stromal cells of transgenic mice can improve the cognitive ability of an Alzheimer's disease rat model.

Authors:  Qing-Ying Wu; Jin Li; Zhong-Tang Feng; Ting-Hua Wang
Journal:  Neurosci Lett       Date:  2007-03-18       Impact factor: 3.046

10.  Distribution and metabolism patterns of plasma 7S- and beta-NGF in the adult male rat.

Authors:  P Pradier; I Jalenques; M Dalle; R Reuling; G Despres; R Romand
Journal:  J Physiol Paris       Date:  1994
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  4 in total

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Journal:  Neurochem Res       Date:  2010-07-24       Impact factor: 3.996

2.  Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway.

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Journal:  Mol Cell Biochem       Date:  2013-08-10       Impact factor: 3.396

Review 3.  Gene-based therapy of Parkinson's Disease: Translation from animal model to human clinical trial employing convection enhanced delivery.

Authors:  Gurwattan S Miranpuri; Lauren Kumbier; Angelica Hinchman; Dominic Schomberg; Anyi Wang; Hope Marshall; Ken Kubota; Chris Ross; Karl Sillay
Journal:  Ann Neurosci       Date:  2012-07

4.  Inflammation biomarker discovery in Parkinson's disease and atypical parkinsonisms.

Authors:  Anna Santaella; H Bea Kuiperij; Anouke van Rumund; Rianne A J Esselink; Alain J van Gool; Bastiaan R Bloem; Marcel M Verbeek
Journal:  BMC Neurol       Date:  2020-01-17       Impact factor: 2.474
  4 in total

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