Literature DB >> 17003872

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.

Anna E Stanley1, Laura J Walton, Malek Kourdi Zerikly, Christophe Corre, Gregory L Challis.   

Abstract

The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

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Year:  2006        PMID： 17003872     DOI： 10.1039/b609556a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  16 in total

Review 1.  The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors:  Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal:  Nat Prod Rep       Date:  2014-01       Impact factor: 13.423

2.  Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.

Authors:  Zhong Xu; Yemin Wang; Keith F Chater; Hong-Yu Ou; H Howard Xu; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2017-03-02       Impact factor: 4.792

3.  Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.

Authors:  Jonathan R Whicher; Galina Florova; Paulina K Sydor; Renu Singh; Mamoun Alhamadsheh; Gregory L Challis; Kevin A Reynolds; Janet L Smith
Journal:  J Biol Chem       Date:  2011-05-03       Impact factor: 5.157

Review 4.  Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.

Authors:  Gregory L Challis
Journal:  J Ind Microbiol Biotechnol       Date:  2013-12-10       Impact factor: 3.346

5.  Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer.

Authors:  James H Frederich; Patrick G Harran
Journal:  J Am Chem Soc       Date:  2013-03-01       Impact factor: 15.419

6.  Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.

Authors:  Ya-Wen Lu; Adrianna K San Roman; Amy M Gehring
Journal:  J Bacteriol       Date:  2008-08-08       Impact factor: 3.490

7.  Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor.

Authors:  Xijun Ou; Bo Zhang; Lin Zhang; Guoping Zhao; Xiaoming Ding
Journal:  Appl Environ Microbiol       Date:  2009-02-05       Impact factor: 4.792

8.  Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry.

Authors:  Kan Chen; Nalaka S Rannulu; Yang Cai; Pat Lane; Andrea L Liebl; Bernard B Rees; Christophe Corre; Gregory L Challis; Richard B Cole
Journal:  J Am Soc Mass Spectrom       Date:  2008-08-09       Impact factor: 3.109

Review 9.  Prodigiosin and its potential applications.

Authors:  N Darshan; H K Manonmani
Journal:  J Food Sci Technol       Date:  2015-01-24       Impact factor: 2.701

Review 10.  Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.

Authors:  Dennis X Hu; David M Withall; Gregory L Challis; Regan J Thomson
Journal:  Chem Rev       Date:  2016-06-17       Impact factor: 60.622
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