OBJECTIVE: To determine whether day 3 embryos exhibiting early compaction have an improved implantation potential compared to embryos without compaction. DESIGN: A retrospective cohort study. SETTING: Hospital-based academic medical center. PATIENT(S): Women <38 years of age undergoing IVF cycles between November 2001 and December 2004 having a day 3 transfer of one or two embryos with >8 cells. INTERVENTION(S): Standard IVF protocol. MAIN OUTCOME MEASURE(S): Compaction grading and implantation rates of 1,047 embryos as related to fragmentation of >or= 8-cell embryos in patients with either 0% or 100% implantation. RESULT(S): Compaction grading was strongly associated with implantation potential; however, the direction of this effect depended on the degree of fragmentation. In embryos with <10% fragmentation, implantation rates increased with the degree of compaction (grade 1, 25%; grade 2, 33%; and grade 3, 47%); in embryos with >or=10% fragmentation, the effect was reversed (grade 1, 38%; grade 2, 20%; and grade 3, 9%). CONCLUSION(S): Assessing the degree of compaction can be a valuable addition to traditional morphologic assessment in identifying optimal embryos for transfer on day 3.
OBJECTIVE: To determine whether day 3 embryos exhibiting early compaction have an improved implantation potential compared to embryos without compaction. DESIGN: A retrospective cohort study. SETTING: Hospital-based academic medical center. PATIENT(S): Women <38 years of age undergoing IVF cycles between November 2001 and December 2004 having a day 3 transfer of one or two embryos with >8 cells. INTERVENTION(S): Standard IVF protocol. MAIN OUTCOME MEASURE(S): Compaction grading and implantation rates of 1,047 embryos as related to fragmentation of >or= 8-cell embryos in patients with either 0% or 100% implantation. RESULT(S): Compaction grading was strongly associated with implantation potential; however, the direction of this effect depended on the degree of fragmentation. In embryos with <10% fragmentation, implantation rates increased with the degree of compaction (grade 1, 25%; grade 2, 33%; and grade 3, 47%); in embryos with >or=10% fragmentation, the effect was reversed (grade 1, 38%; grade 2, 20%; and grade 3, 9%). CONCLUSION(S): Assessing the degree of compaction can be a valuable addition to traditional morphologic assessment in identifying optimal embryos for transfer on day 3.
Authors: Juan Carlos Fierro-González; Melanie D White; Juan Carlos Silva; Nicolas Plachta Journal: Nat Cell Biol Date: 2013-11-24 Impact factor: 28.824