Literature DB >> 16978016

Bioactivation of Selective Estrogen Receptor Modulators (SERMs).

Tamara S Dowers1, Zhi-Hui Qin, Gregory R J Thatcher, Judy L Bolton.   

Abstract

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Year:  2006        PMID： 16978016      PMCID： PMC2517576          DOI： 10.1021/tx060126v

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


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  137 in total

1.  Biotransformation of tamoxifen in a human endometrial explant culture model.

Authors:  Minoti Sharma; David E Shubert; Moheswar Sharma; Jennifer Lewis; Barbara P McGarrigle; Diane P Bofinger; James R Olson
Journal:  Chem Biol Interact       Date:  2003-12-15       Impact factor: 5.192

2.  Correspondence regarding M. Sharma et al., "Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture".

Authors:  Karen Brown; Paul L Carmichael
Journal:  Biochem Biophys Res Commun       Date:  2003-10-31       Impact factor: 3.575

3.  Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.

Authors:  Sung Yeon Kim; Naomi Suzuki; Y R Santosh Laxmi; Robert Rieger; Shinya Shibutani
Journal:  Chem Res Toxicol       Date:  2003-09       Impact factor: 3.739

4.  Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture.

Authors:  Minoti Sharma; David E Shubert; Moheswar Sharma; Kerry J Rodabaugh; Barbara P McGarrigle; Chad M Vezina; Diane P Bofinger; James R Olson
Journal:  Biochem Biophys Res Commun       Date:  2003-07-18       Impact factor: 3.575

5.  Evaluation of an estrogen receptor-beta agonist in animal models of human disease.

Authors:  Heather A Harris; Leo M Albert; Yelena Leathurby; Michael S Malamas; Richard E Mewshaw; Chris P Miller; Yogendra P Kharode; James Marzolf; Barry S Komm; Richard C Winneker; Donald E Frail; Ruth A Henderson; Yuan Zhu; James C Keith
Journal:  Endocrinology       Date:  2003-10       Impact factor: 4.736

6.  Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.

Authors:  Xuemei Liu; Emily Pisha; Debra A Tonetti; Dan Yao; Yan Li; Jiaqin Yao; Joanna E Burdette; Judy L Bolton
Journal:  Chem Res Toxicol       Date:  2003-07       Impact factor: 3.739

7.  Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.

Authors:  Jiaqin Yao; Yan Li; Minsun Chang; Huaping Wu; Xiaofeng Yang; Julie E Goodman; Xuemei Liu; Hong Liu; Andrew D Mesecar; Richard B Van Breemen; James D Yager; Judy L Bolton
Journal:  Chem Res Toxicol       Date:  2003-05       Impact factor: 3.739

Review 8.  Arzoxifene as therapy for endometrial cancer.

Authors:  Thomas W Burke; Cheryl L Walker
Journal:  Gynecol Oncol       Date:  2003-08       Impact factor: 5.482

9.  A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer.

Authors:  D Scott McMeekin; Alan Gordon; Jeffrey Fowler; Allen Melemed; Richard Buller; Thomas Burke; Jeffery Bloss; Paul Sabbatini
Journal:  Gynecol Oncol       Date:  2003-07       Impact factor: 5.482

10.  Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.

Authors:  J Baselga; A Llombart-Cussac; M Bellet; V Guillem-Porta; N Enas; K Krejcy; E Carrasco; L Kayitalire; M Kuta; A Lluch; P Vodvarka; P Kerbrat; M Namer; L Petruzelka
Journal:  Ann Oncol       Date:  2003-09       Impact factor: 32.976
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  19 in total

1.  The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.

Authors:  Teshome B Gherezghiher; Bradley Michalsen; R Esala P Chandrasena; Zhihui Qin; Johann Sohn; Gregory R J Thatcher; Judy L Bolton
Journal:  Chem Biol Interact       Date:  2012-01-28       Impact factor: 5.192

2.  Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol.

Authors:  Bradley T Michalsen; Teshome B Gherezghiher; Jaewoo Choi; R Esala P Chandrasena; Zhihui Qin; Gregory R J Thatcher; Judy L Bolton
Journal:  Chem Res Toxicol       Date:  2012-06-14       Impact factor: 3.739

3.  Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1).

Authors:  Edwin J Squirewell; Xiaoyan Qin; Michael W Duffel
Journal:  Drug Metab Dispos       Date:  2014-08-25       Impact factor: 3.922

4.  Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.

Authors:  Bolan Yu; Zhihui Qin; Gihani T Wijewickrama; Praneeth Edirisinghe; Judy L Bolton; Gregory R J Thatcher
Journal:  Bioconjug Chem       Date:  2009-04       Impact factor: 4.774

5.  Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism.

Authors:  Ramy Abdelhamid; Jia Luo; Lawren Vandevrede; Indraneel Kundu; Bradley Michalsen; Vladislav A Litosh; Isaac T Schiefer; Teshome Gherezghiher; Ping Yao; Zhihui Qin; Gregory R J Thatcher
Journal:  ACS Chem Neurosci       Date:  2011-05-18       Impact factor: 4.418

6.  Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?

Authors:  Judy L Bolton
Journal:  Curr Org Chem       Date:  2014-01-01       Impact factor: 2.180

7.  Unraveling Reversible DNA Cross-Links with a Biological Machine.

Authors:  Shane R Byrne; Steven E Rokita
Journal:  Chem Res Toxicol       Date:  2020-11-05       Impact factor: 3.739

8.  TARGETING THE GENOTOXIC EFFECTS OF ESTROGENS.

Authors:  Monica M Montano; Nirmala Krishnamurthy; Smitha Sripathy
Journal:  Drug Discov Today Dis Mech       Date:  2012

9.  Construction of a database for the evaluation and the clinical management of patients with breast cancer treated with antiestrogens and/or aromatase inhibitors.

Authors:  Francesca Giusti; Silva Ottanelli; Laura Masi; Antonietta Amedei; Maria Luisa Brandi; Alberto Falchetti
Journal:  Clin Cases Miner Bone Metab       Date:  2011-01

10.  Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites.

Authors:  Bo-lan Yu; Zi-xin Mai; Xu-xiang Liu; Zhao-feng Huang
Journal:  Acta Pharmacol Sin       Date:  2013-01-21       Impact factor: 6.150
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