Literature DB >> 23795205

TARGETING THE GENOTOXIC EFFECTS OF ESTROGENS.

Monica M Montano1, Nirmala Krishnamurthy, Smitha Sripathy.   

Abstract

Our studies indicate that expression of antioxidative stress enzymes is upregulated by Selective Estrogen Receptor Modulators (SERMs) in breast epithelial cell lines, providing protection against the genotoxic effects of estrogens and against estrogen-induced mammary tumorigenesis. This upregulation of antioxidative stress enzymes requires Estrogen Receptor beta (ERβ) and human homolog of Xenopus gene which Prevents Mitotic Catastrophe (hPMC2). Further studies indicate that hPMC2 has a functional exonuclease domain that is required for upregulation of antioxidative stress enzymes by SERMs and repair of estrogen-induced abasic sites.

Entities:  

Year:  2012        PMID： 23795205      PMCID： PMC3685422          DOI： 10.1016/j.ddmec.2012.11.005

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  53 in total

Review 1.  Antioxidants and oxidants regulated signal transduction pathways.

Authors:  Edward D Owuor; Ah-Ng Tony Kong
Journal:  Biochem Pharmacol       Date:  2002-09       Impact factor: 5.858

2.  A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

Authors:  Bong-Gun Ju; Victoria V Lunyak; Valentina Perissi; Ivan Garcia-Bassets; David W Rose; Christopher K Glass; Michael G Rosenfeld
Journal:  Science       Date:  2006-06-23       Impact factor: 47.728

Review 3.  DNA repair nucleases.

Authors:  T M Marti; O Fleck
Journal:  Cell Mol Life Sci       Date:  2004-02       Impact factor: 9.261

Review 4.  Clinical significance of estrogen receptor beta in breast cancer.

Authors:  Shigehira Saji; Makiko Hirose; Masakazu Toi
Journal:  Cancer Chemother Pharmacol       Date:  2005-11       Impact factor: 3.333

Review 5.  Functional role of estrogen metabolism in target cells: review and perspectives.

Authors:  B T Zhu; A H Conney
Journal:  Carcinogenesis       Date:  1998-01       Impact factor: 4.944

Review 6.  Estrogens as endogenous genotoxic agents--DNA adducts and mutations.

Authors:  E Cavalieri; K Frenkel; J G Liehr; E Rogan; D Roy
Journal:  J Natl Cancer Inst Monogr       Date:  2000

7.  The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.

Authors:  M J Moser; W R Holley; A Chatterjee; I S Mian
Journal:  Nucleic Acids Res       Date:  1997-12-15       Impact factor: 16.971

8.  Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis.

Authors:  M M Montano; L J Chaplin; H Deng; S Mesia-Vela; N Gaikwad; M Zahid; E Rogan
Journal:  Oncogene       Date:  2006-12-11       Impact factor: 9.867

9.  The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer.

Authors:  L Nakopoulou; A C Lazaris; E G Panayotopoulou; I Giannopoulou; N Givalos; S Markaki; A Keramopoulos
Journal:  J Clin Pathol       Date:  2004-05       Impact factor: 3.411

10.  In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol.

Authors:  Sheila Dawling; David L Hachey; Nady Roodi; Fritz F Parl
Journal:  Chem Res Toxicol       Date:  2004-09       Impact factor: 3.739
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  1 in total

1.  Preface.

Authors:  Ercole Cavalieri; Eleanor G Rogan
Journal:  Drug Discov Today Dis Mech       Date:  2012-12-22
  1 in total

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