OBJECTIVE: To present a decision support system for optimising mechanical ventilation in patients residing in the intensive care unit. METHODS: Mathematical models of oxygen transport, carbon dioxide transport and lung mechanics are combined with penalty functions describing clinical preference toward the goals and side-effects of mechanical ventilation in a decision theoretic approach. Penalties are quantified for risk of lung barotrauma, acidosis or alkalosis, oxygen toxicity or absorption atelectasis, and hypoxaemia. RESULTS: The system is presented with an example of its use in a post-surgical patient. The mathematical models describe the patient's data, and the system suggests an optimal ventilator strategy in line with clinical practice. CONCLUSIONS: The system illustrates how mathematical models combined with decision theory can aid in the difficult compromises necessary when deciding on ventilator settings.
OBJECTIVE: To present a decision support system for optimising mechanical ventilation in patients residing in the intensive care unit. METHODS: Mathematical models of oxygen transport, carbon dioxide transport and lung mechanics are combined with penalty functions describing clinical preference toward the goals and side-effects of mechanical ventilation in a decision theoretic approach. Penalties are quantified for risk of lung barotrauma, acidosis or alkalosis, oxygentoxicity or absorption atelectasis, and hypoxaemia. RESULTS: The system is presented with an example of its use in a post-surgical patient. The mathematical models describe the patient's data, and the system suggests an optimal ventilator strategy in line with clinical practice. CONCLUSIONS: The system illustrates how mathematical models combined with decision theory can aid in the difficult compromises necessary when deciding on ventilator settings.
Authors: S Kjaergaard; S E Rees; J A Nielsen; M Freundlich; P Thorgaard; S Andreassen Journal: Acta Anaesthesiol Scand Date: 2001-03 Impact factor: 2.105
Authors: S Andreassen; S E Rees; S Kjaergaard; P Thorgaard; S M Winter; C J Morgan; P Alstrup; E Toft Journal: Crit Care Med Date: 1999-11 Impact factor: 7.598
Authors: S Kjaergaard; S E Rees; J Grønlund; E M Nielsen; P Lambert; P Thorgaard; E Toft; S Andreassen Journal: Eur J Anaesthesiol Date: 2004-04 Impact factor: 4.330
Authors: G W Rutledge; G E Thomsen; B R Farr; M A Tovar; J X Polaschek; I A Beinlich; L B Sheiner; L M Fagan Journal: Artif Intell Med Date: 1993-02 Impact factor: 5.326
Authors: Lars P Thomsen; Dan S Karbing; Bram W Smith; David Murley; Ulla M Weinreich; Søren Kjærgaard; Egon Toft; Per Thorgaard; Steen Andreassen; Stephen E Rees Journal: J Clin Monit Comput Date: 2013-02-21 Impact factor: 2.502
Authors: Dan S Karbing; Charlotte Allerød; Lars P Thomsen; Kurt Espersen; Per Thorgaard; Steen Andreassen; Søren Kjærgaard; Stephen E Rees Journal: Med Biol Eng Comput Date: 2011-11-22 Impact factor: 2.602
Authors: Michael J Banner; Neil R Euliano; David Grooms; A Daniel Martin; Nawar Al-Rawas; Andrea Gabrielli Journal: J Clin Monit Comput Date: 2013-10-18 Impact factor: 2.502
Authors: Alan H Morris; Brian Stagg; Michael Lanspa; James Orme; Terry P Clemmer; Lindell K Weaver; Frank Thomas; Colin K Grissom; Ellie Hirshberg; Thomas D East; Carrie Jane Wallace; Michael P Young; Dean F Sittig; Antonio Pesenti; Michela Bombino; Eduardo Beck; Katherine A Sward; Charlene Weir; Shobha S Phansalkar; Gordon R Bernard; B Taylor Thompson; Roy Brower; Jonathon D Truwit; Jay Steingrub; R Duncan Hite; Douglas F Willson; Jerry J Zimmerman; Vinay M Nadkarni; Adrienne Randolph; Martha A Q Curley; Christopher J L Newth; Jacques Lacroix; Michael S D Agus; Kang H Lee; Bennett P deBoisblanc; R Scott Evans; Dean K Sorenson; Anthony Wong; Michael V Boland; David W Grainger; Willard H Dere; Alan S Crandall; Julio C Facelli; Stanley M Huff; Peter J Haug; Ulrike Pielmeier; Stephen E Rees; Dan S Karbing; Steen Andreassen; Eddy Fan; Roberta M Goldring; Kenneth I Berger; Beno W Oppenheimer; E Wesley Ely; Ognjen Gajic; Brian Pickering; David A Schoenfeld; Irena Tocino; Russell S Gonnering; Peter J Pronovost; Lucy A Savitz; Didier Dreyfuss; Arthur S Slutsky; James D Crapo; Derek Angus; Michael R Pinsky; Brent James; Donald Berwick Journal: J Am Med Inform Assoc Date: 2021-06-12 Impact factor: 4.497