Literature DB >> 16960656

Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses.

Mohammad Nazir Hossain1, Michihiko Fuji, Kensuke Miki, Morio Endoh, Dai Ayusawa.   

Abstract

The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulations of certain mRNA species. We studied its role in stress response using siRNA mediated knockdown approach in HeLa cells. Upon transient transfection with plasmid encoding siRNA, the cells showed increased sensitivities to various chemical agents, namely H(2)O(2, )paraquat, camptothecin, ICRF-193 and halogenated deoxyuridines. These results demonstrate that hnRNP C1/C2 is involved in maintenance of cellular homeostasis besides cellular differentiation and proliferation.

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Year:  2006        PMID： 16960656     DOI： 10.1007/s11010-006-9308-2

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  33 in total

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Journal:  EMBO Rep       Date:  2001-10       Impact factor: 8.807

Review 3.  Messenger-RNA-binding proteins and the messages they carry.

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Journal:  Nat Rev Mol Cell Biol       Date:  2002-03       Impact factor: 94.444

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5.  DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts.

Authors:  E Michishita; K Nakabayashi; H Ogino; T Suzuki; M Fujii; D Ayusawa
Journal:  Biochem Biophys Res Commun       Date:  1998-12-30       Impact factor: 3.575

6.  A major determinant of hnRNP C protein binding to RNA is a novel bZIP-like RNA binding domain.

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Journal:  RNA       Date:  1996-11       Impact factor: 4.942

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Review 8.  The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress.

Authors:  K J Davies
Journal:  IUBMB Life       Date:  1999-07       Impact factor: 3.885

9.  Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.

Authors:  Noritaka Adachi; Hiromi Suzuki; Susumu Iiizumi; Hideki Koyama
Journal:  J Biol Chem       Date:  2003-07-03       Impact factor: 5.157

10.  Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.

Authors:  Jong Heon Kim; Ki Young Paek; Kobong Choi; Tae-Don Kim; Bumsuk Hahm; Kyong-Tai Kim; Sung Key Jang
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272
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  11 in total

1.  The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.

Authors:  Reed S Shabman; Erol E Gulcicek; Kathryn L Stone; Christopher F Basler
Journal:  J Infect Dis       Date:  2011-11       Impact factor: 5.226

2.  Paraoxon-induced protein expression changes to SH-SY5Y cells.

Authors:  John M Prins; Kathleen M George; Charles M Thompson
Journal:  Chem Res Toxicol       Date:  2010-10-08       Impact factor: 3.739

3.  A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

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Journal:  Mol Cell       Date:  2009-07-31       Impact factor: 17.970

4.  Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia.

Authors:  Mikhail P Panchenko; Nilsa Silva; James R Stone
Journal:  Cardiovasc Pathol       Date:  2008-05-27       Impact factor: 2.185

5.  Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.

Authors:  Sherly Mosessian; Nuraly K Avliyakulov; David J Mulholland; Pinmanee Boontheung; Joseph A Loo; Hong Wu
Journal:  J Biol Chem       Date:  2009-09-09       Impact factor: 5.157

6.  Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.

Authors:  David S Phelps; Todd M Umstead; Joanna Floros
Journal:  J Proteomics       Date:  2014-06-18       Impact factor: 4.044

7.  Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R.

Authors:  José M Izquierdo
Journal:  Nucleic Acids Res       Date:  2010-08-10       Impact factor: 16.971

8.  Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells.

Authors:  DA-Quan Sun; Ying Wang; Ding-Gan Liu
Journal:  Oncol Lett       Date:  2013-01-31       Impact factor: 2.967

9.  Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

Authors:  Rachel W Anantha; Allen L Alcivar; Jianglin Ma; Hong Cai; Srilatha Simhadri; Jernej Ule; Julian König; Bing Xia
Journal:  PLoS One       Date:  2013-04-09       Impact factor: 3.240

10.  hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang.

Authors:  Richard E Mulnix; Ryan T Pitman; Allison Retzer; Ceyda Bertram; Kavin Arasi; Zachary Crees; Jennifer Girard; Srijayaprakash B Uppada; Amanda L Stone; Neelu Puri
Journal:  Onco Targets Ther       Date:  2013-12-18       Impact factor: 4.147
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