| Literature DB >> 1695442 |
E Masini1, S Bianchi, F Gambassi, B Palmerani, A Pistelli, L Carlomagno, P F Mannaioni.
Abstract
Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions.Entities:
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Year: 1990 PMID: 1695442 DOI: 10.1007/bf01969037
Source DB: PubMed Journal: Agents Actions ISSN: 0065-4299