Literature DB >> 2473620

Ischemia-reperfusion injury and histamine release in isolated guinea-pig heart: the role of free radicals.

E Masini1, F Gambassi, E Giannella, B Palmerani, A Pistelli, L Carlomagno, P F Mannaioni.   

Abstract

Free radicals produced by the occlusion and opening of the left anterior descending coronary artery and/or by perfusion of isolated guinea-pig heart with FeCl3/ADP (10 microM/100 microM) induce a differential release of histamine and lactate dehydrogenase (LDH) in the perfusates with a preferential liberation of histamine in the reperfusion phase, associated with an increase of ventricular arrhythmias. The release of histamine has been correlated with malonyldialdehyde (MDA) production and tissue calcium content in left ventricular tissue. MDA increased during ischemia, while the calcium content increased when the tissue was reperfused. Under these conditions, N-t-butyl-alpha-phenylnitrone (BPN), a molecule capable of forming spin adducts with free radicals, and D-mannitol are active in preventing reperfusion-induced arrhythmias.

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Year:  1989        PMID： 2473620     DOI： 10.1007/bf02222225

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Histamine and lactate dehydrogenase (LDH) release in ischemic myocardium of the guinea-pig.

Authors:  E Masini; E Giannella; S Bianchi; P F Mannaioni
Journal:  Agents Actions       Date:  1987-04

Review 2.  Free radicals as endogenous histamine releasers.

Authors:  P F Mannaioni; E Giannella; B Palmerani; A Pistelli; F Gambassi; T Bani-Sacchi; S Bianchi; E Masini
Journal:  Agents Actions       Date:  1988-04

Review 3.  Free radicals and myocardial ischemia: overview and outlook.

Authors:  J M McCord
Journal:  Free Radic Biol Med       Date:  1988       Impact factor: 7.376

4.  Histamine release during an experimental coronary thrombosis in awake dog.

Authors:  E Masini; J Phanchenault; F Pezziardi; P Gautier; J P Gagnol
Journal:  Agents Actions       Date:  1985-04

5.  Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Authors:  J L Zweier; J T Flaherty; M L Weisfeldt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

6.  Hydrogen peroxide has a role in the aggregation of human platelets.

Authors:  D Del Principe; A Menichelli; W De Matteis; M L Di Corpo; S Di Giulio; A Finazzi-Agro
Journal:  FEBS Lett       Date:  1985-06-03       Impact factor: 4.124

7.  Histamine release in acute coronary occlusion-reperfusion in isolated guinea-pig heart.

Authors:  E Masini; E Giannella; S Bianchi; B Palmerani; A Pistelli; P F Mannaioni
Journal:  Agents Actions       Date:  1988-04

8.  Production of free radicals and lipid peroxides in early experimental myocardial ischemia.

Authors:  P S Rao; M V Cohen; H S Mueller
Journal:  J Mol Cell Cardiol       Date:  1983-10       Impact factor: 5.000

9.  Myocardial recovery during post-ischaemic reperfusion: effects of nifedipine, calcium and magnesium.

Authors:  R Ferrari; A Albertini; S Curello; C Ceconi; F Di Lisa; R Raddino; O Visioli
Journal:  J Mol Cell Cardiol       Date:  1986-05       Impact factor: 5.000
  9 in total
  6 in total

1.  Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions.

Authors:  E Masini; S Bianchi; F Gambassi; B Palmerani; A Pistelli; L Carlomagno; P F Mannaioni
Journal:  Agents Actions       Date:  1990-04

2.  Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart.

Authors:  D Bani; E Masini; M G Bello; M Bigazzi; T B Sacchi
Journal:  Am J Pathol       Date:  1998-05       Impact factor: 4.307

3.  Open heart surgery increases the levels of histamine in arterial and coronary sinus blood.

Authors:  G Valen; J Kaszaki; S Nagy; J Vaage
Journal:  Agents Actions       Date:  1994-03

4.  Cardiac release of histamine after ventricular fibrillation and defibrillation during insertion of implantable cardioverter defibrillators (ICD).

Authors:  G Valen; M Runsiö; A Owall; J Kaszaki; S Nagy; M Rosenqvist; L Bergfeldt; J Vaage
Journal:  Inflamm Res       Date:  1995-11       Impact factor: 4.575

5.  Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo.

Authors:  Emanuela Masini; Salvatore Cuzzocrea; Emanuela Mazzon; Cosimo Marzocca; Pier Francesco Mannaioni; Daniela Salvemini
Journal:  Br J Pharmacol       Date:  2002-07       Impact factor: 8.739

6.  The effects of exogenous histamine in isolated rat hearts.

Authors:  G Valen; T Skjelbakken; J Vaage
Journal:  Mol Cell Biochem       Date:  1995-05-10       Impact factor: 3.396
  6 in total

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