Literature DB >> 16954315

Novel streptomycin resistance gene from Mycobacterium fortuitum.

Santiago Ramón-García1, Isabel Otal, Carlos Martín, Rafael Gómez-Lus, José A Aínsa.   

Abstract

We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.

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Year:  2006        PMID： 16954315      PMCID： PMC1635185          DOI： 10.1128/AAC.00223-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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