BACKGROUND: Although it is widely assumed that childhood sensitization to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVE: We sought to assess the role of early exposure to 2 major household aeroallergens (Der p 1 and Fel d 1) in sensitization at the age of 4 years. METHODS: Pregnant women and their children were recruited for the Asthma Multicenter Infant Cohort Study. Three cohorts (Ashford in the United Kingdom and Menorca and Barcelona in Spain) followed the same research protocol. A total of 1611 newborn children were initially included in the cohort, from whose homes we collected dust samples at 3 months of age for 1474; Der p 1 and Fel d 1 levels were measured. Of these children, we obtained blood for specific IgE determination in 1019. RESULTS: The risk of Fel d 1 sensitization increased with exposure in a nonlinear manner. No association was found between specific IgE to Der p 1 and aeroallergen levels of exposure at early life in 2 centers, but a positive association was observed in the third. CONCLUSIONS: The dose-response relationships between allergen exposure and sensitization differ between allergens and might vary between different locales. The hypothesis that sensitization to house dust mite is directly related to levels of allergen exposure might not apply to the general population or to different ranges of exposure. CLINICAL IMPLICATIONS: Aeroallergen avoidance might not have any important effect on the incidence of sensitization.
BACKGROUND: Although it is widely assumed that childhood sensitization to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVE: We sought to assess the role of early exposure to 2 major household aeroallergens (Der p 1 and Fel d 1) in sensitization at the age of 4 years. METHODS: Pregnant women and their children were recruited for the Asthma Multicenter Infant Cohort Study. Three cohorts (Ashford in the United Kingdom and Menorca and Barcelona in Spain) followed the same research protocol. A total of 1611 newborn children were initially included in the cohort, from whose homes we collected dust samples at 3 months of age for 1474; Der p 1 and Fel d 1 levels were measured. Of these children, we obtained blood for specific IgE determination in 1019. RESULTS: The risk of Fel d 1 sensitization increased with exposure in a nonlinear manner. No association was found between specific IgE to Der p 1 and aeroallergen levels of exposure at early life in 2 centers, but a positive association was observed in the third. CONCLUSIONS: The dose-response relationships between allergen exposure and sensitization differ between allergens and might vary between different locales. The hypothesis that sensitization to house dust mite is directly related to levels of allergen exposure might not apply to the general population or to different ranges of exposure. CLINICAL IMPLICATIONS: Aeroallergen avoidance might not have any important effect on the incidence of sensitization.
Authors: Ana Elisa Fusaro; Cyro Alves de Brito; Eliana Futata Taniguchi; Bruno Pacola Muniz; Jefferson Russo Victor; Noemia Mie Orii; Alberto José da Silva Duarte; Maria Notomi Sato Journal: Immunology Date: 2008-12-18 Impact factor: 7.397
Authors: Jay Portnoy; Kevin Kennedy; James Sublett; Wanda Phipatanakul; Elizabeth Matsui; Charles Barnes; Carl Grimes; J David Miller; James M Seltzer; P Brock Williams; Jonathan A Bernstein; David I Bernstein; Joann Blessing-Moore; Linda Cox; David A Khan; David M Lang; Richard A Nicklas; John Oppenheimer Journal: Ann Allergy Asthma Immunol Date: 2012-04 Impact factor: 6.347
Authors: Gary M Hunninghake; Manuel E Soto-Quirós; Jessica Lasky-Su; Lydiana Avila; Ngoc P Ly; Catherine Liang; Barbara J Klanderman; Benjamin A Raby; Diane R Gold; Scott T Weiss; Juan C Celedón Journal: J Allergy Clin Immunol Date: 2008-04-28 Impact factor: 10.793
Authors: Matthew S Perzanowski; Ginger L Chew; Adnan Divjan; Kyung Hwa Jung; Robert Ridder; Deliang Tang; Diurka Diaz; Inge F Goldstein; Patrick L Kinney; Andrew G Rundle; David E Camann; Frederica P Perera; Rachel L Miller Journal: J Allergy Clin Immunol Date: 2013-02-04 Impact factor: 10.793
Authors: Junenette L Peters; Shakira Franco Suglia; Thomas A E Platts-Mills; Jacob Hosen; Diane R Gold; Rosalind J Wright Journal: J Allergy Clin Immunol Date: 2009-04-10 Impact factor: 10.793
Authors: Matthew S Perzanowski; Ginger L Chew; Adnan Divjan; Alina Johnson; Inge F Goldstein; Robin S Garfinkel; Lori A Hoepner; Thomas A E Platts-Mills; Frederica P Perera; Rachel L Miller Journal: J Allergy Clin Immunol Date: 2008-04 Impact factor: 10.793