BACKGROUND: The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10). OBJECTIVES: To evaluate whether dust mite exposure modifies the effect of single nucleotide polymorphisms (SNPs) in IL10 on allergy and asthma exacerbations. METHODS: We genotyped 6 SNPs in IL10 in 417 Costa Rican children and 503 white children in the Childhood Asthma Management Program (CAMP) with asthma and their parents. We used family-based and population-based approaches to test for interactions between IL10 SNPs and dust mite allergen on serum IgE to dust mite in Costa Rica and on asthma exacerbations in Costa Rica and CAMP. RESULTS: Dust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496) and IgE to dust mite in Costa Rica (P for interaction, .0004 for SNP rs1800896). For each of these SNPs, homozygosity for the minor allele was associated with increased levels of IgE to dust mite with increased dust mite exposure. Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence (approximately 3-fold to 39-fold increase) and frequency of asthma exacerbations among children exposed to > or = 10 microg/g dust mite allergen in Costa Rica. Similar results were obtained for 2 of these SNPs (rs1800896 and rs3024496) among white children in CAMP. CONCLUSION: Our findings suggest that dust mite allergen levels modify the effect of IL10 SNPs on allergy and asthma exacerbations and may partly explain conflicting findings in this field.
BACKGROUND: The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10). OBJECTIVES: To evaluate whether dust mite exposure modifies the effect of single nucleotide polymorphisms (SNPs) in IL10 on allergy and asthma exacerbations. METHODS: We genotyped 6 SNPs in IL10 in 417 Costa Rican children and 503 white children in the Childhood Asthma Management Program (CAMP) with asthma and their parents. We used family-based and population-based approaches to test for interactions between IL10 SNPs and dust mite allergen on serum IgE to dust mite in Costa Rica and on asthma exacerbations in Costa Rica and CAMP. RESULTS: Dust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496) and IgE to dust mite in Costa Rica (P for interaction, .0004 for SNP rs1800896). For each of these SNPs, homozygosity for the minor allele was associated with increased levels of IgE to dust mite with increased dust mite exposure. Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence (approximately 3-fold to 39-fold increase) and frequency of asthma exacerbations among children exposed to > or = 10 microg/g dust mite allergen in Costa Rica. Similar results were obtained for 2 of these SNPs (rs1800896 and rs3024496) among white children in CAMP. CONCLUSION: Our findings suggest that dust mite allergen levels modify the effect of IL10 SNPs on allergy and asthma exacerbations and may partly explain conflicting findings in this field.
Authors: Juan C Celedón; Donald K Milton; Clare D Ramsey; Augusto A Litonjua; Louise Ryan; Thomas A E Platts-Mills; Diane R Gold Journal: J Allergy Clin Immunol Date: 2007-05-15 Impact factor: 10.793
Authors: C J M Antens; M Oldenwening; A Wolse; U Gehring; H A Smit; R C Aalberse; M Kerkhof; J Gerritsen; J C de Jongste; B Brunekreef Journal: Clin Exp Allergy Date: 2006-12 Impact factor: 5.018
Authors: H Hakonarson; U S Bjornsdottir; E Ostermann; T Arnason; A E Adalsteinsdottir; E Halapi; D Shkolny; K Kristjansson; S A Gudnadottir; M L Frigge; D Gislason; T Gislason; A Kong; J Gulcher; K Stefansson Journal: Am J Respir Crit Care Med Date: 2001-12-01 Impact factor: 21.405
Authors: Luis G Carvajal-Carmona; Roel Ophoff; Susan Service; Jaana Hartiala; Julio Molina; Pedro Leon; Jorge Ospina; Gabriel Bedoya; Nelson Freimer; Andrés Ruiz-Linares Journal: Hum Genet Date: 2003-02-25 Impact factor: 4.132
Authors: J Eskdale; G Gallagher; C L Verweij; V Keijsers; R G Westendorp; T W Huizinga Journal: Proc Natl Acad Sci U S A Date: 1998-08-04 Impact factor: 11.205
Authors: C M Luczynska; L K Arruda; T A Platts-Mills; J D Miller; M Lopez; M D Chapman Journal: J Immunol Methods Date: 1989-03-31 Impact factor: 2.303
Authors: Melissa D Johnson; Theo S Plantinga; Esther van de Vosse; Digna R Velez Edwards; P Brian Smith; Barbara D Alexander; John C Yang; Dennis Kremer; Gregory M Laird; Marije Oosting; Leo A B Joosten; Jos W M van der Meer; Jaap T van Dissel; Thomas J Walsh; John R Perfect; Bart-Jan Kullberg; William K Scott; Mihai G Netea Journal: Clin Infect Dis Date: 2011-12-05 Impact factor: 9.079
Authors: Fred D Finkelman; Simon P Hogan; Gurjit K Khurana Hershey; Marc E Rothenberg; Marsha Wills-Karp Journal: J Immunol Date: 2010-02-15 Impact factor: 5.422
Authors: Erick Forno; Mudita Gogna; Alfonso Cepeda; Anahi Yañez; Dirceu Solé; Philip Cooper; Lydiana Avila; Manuel Soto-Quiros; Jose A Castro-Rodriguez; Juan C Celedón Journal: Thorax Date: 2015-06-23 Impact factor: 9.139
Authors: Joanne E Sordillo; Roxanne Kelly; Supinda Bunyavanich; Michael McGeachie; Weiliang Qiu; Damien C Croteau-Chonka; Manuel Soto-Quiros; Lydiana Avila; Juan C Celedón; John M Brehm; Scott T Weiss; Diane R Gold; Augusto A Litonjua Journal: J Allergy Clin Immunol Date: 2015-04-24 Impact factor: 10.793
Authors: Sunita Sharma; Benjamin A Raby; Gary M Hunninghake; Manuel Soto-Quirós; Lydiana Avila; Amy J Murphy; Jessica Lasky-Su; Barbara J Klanderman; Jody S Sylvia; Scott T Weiss; Juan C Celedón Journal: Am J Respir Crit Care Med Date: 2008-12-18 Impact factor: 21.405