| Literature DB >> 16940125 |
Chedly Chouchani1, Renaud Berlemont, Afef Masmoudi, Moreno Galleni, Jean-Marie Frere, Omrane Belhadj, Kamel Ben-Mahrez.
Abstract
A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N175I, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.Entities:
Mesh:
Substances:
Year: 2006 PMID: 16940125 PMCID: PMC1563563 DOI: 10.1128/AAC.00388-06
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191