PURPOSE: To present a calorimetry-based approach for estimating the initial (at the onset of annealing) relaxation time (tau (0)) of organic amorphous solids at relatively low temperatures, and to assess the temperature where molecular mobility of the amorphous drug is reduced to a level comparable with the desired shelf-life of the product. MATERIALS AND METHODS: Values of tau (0) for six amorphous pharmaceutical compounds were estimated based on the nonlinear Adam-Gibbs equation. Fragility was determined from the scanning rate-dependence of the glass transition temperature (T (g)). The initial enthalpic and entropic fictive temperatures were obtained from the T (g) and the heat capacities (C (p)) of the amorphous and crystalline forms. RESULTS: At a relatively low temperature ( approximately 40 degrees C or more below T (g)), tau (0) for the different compounds varies by over an order of magnitude. For some materials, the practical storage temperature at T (g) - 50 K was found to be still too high to ensure long-term stability. The estimated tau (0) is highly sensitive to the fragility of the material and the C (p) of the crystalline and amorphous forms. Materials with high fragility or greater C (p) differences between crystalline and amorphous forms tend to have longer tau (0). CONCLUSIONS: The proposed method can be used to estimate molecular mobility at relatively low temperatures without having to conduct enthalpy recovery experiments. An accurate tau (0) determination from this method relies on faithful fragility measurements.
PURPOSE: To present a calorimetry-based approach for estimating the initial (at the onset of annealing) relaxation time (tau (0)) of organic amorphous solids at relatively low temperatures, and to assess the temperature where molecular mobility of the amorphous drug is reduced to a level comparable with the desired shelf-life of the product. MATERIALS AND METHODS: Values of tau (0) for six amorphous pharmaceutical compounds were estimated based on the nonlinear Adam-Gibbs equation. Fragility was determined from the scanning rate-dependence of the glass transition temperature (T (g)). The initial enthalpic and entropic fictive temperatures were obtained from the T (g) and the heat capacities (C (p)) of the amorphous and crystalline forms. RESULTS: At a relatively low temperature ( approximately 40 degrees C or more below T (g)), tau (0) for the different compounds varies by over an order of magnitude. For some materials, the practical storage temperature at T (g) - 50 K was found to be still too high to ensure long-term stability. The estimated tau (0) is highly sensitive to the fragility of the material and the C (p) of the crystalline and amorphous forms. Materials with high fragility or greater C (p) differences between crystalline and amorphous forms tend to have longer tau (0). CONCLUSIONS: The proposed method can be used to estimate molecular mobility at relatively low temperatures without having to conduct enthalpy recovery experiments. An accurate tau (0) determination from this method relies on faithful fragility measurements.
Authors: Xin Feng; Xingyou Ye; Jun-Bom Park; Wenli Lu; Joe Morott; Brad Beissner; Zhuoyang John Lian; Elanor Pinto; Vivian Bi; Stu Porter; Tom Durig; Soumyajit Majumdar; Michael A Repka Journal: Drug Dev Ind Pharm Date: 2015-07-21 Impact factor: 3.225