Literature DB >> 9002452

Characteristics and significance of the amorphous state in pharmaceutical systems.

B C Hancock1, G Zografi.   

Abstract

The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms. This review describes the characteristics of the amorphous state and some of the most common methods that can be used to measure them. Examples of pharmaceutical situations where the presence of the amorphous state plays an important role are presented. The application of our current knowledge to pharmaceutical formulation problems is illustrated, and some strategies for working with amorphous character in pharmaceutical systems are provided.

Mesh：

Year:  1997        PMID： 9002452     DOI： 10.1021/js9601896

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  199 in total

1.  Differences in crystallization behavior between quenched and ground amorphous ursodeoxycholic acid.

Authors:  E Yonemochi; Y Inoue; G Buckton; A Moffat; T Oguchi; K Yamamoto
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

2.  Effect of the storage conditions on the tensile strength of tablets in relation to the enthalpy relaxation of the binder.

Authors:  F Kiekens; R Zelko; J P Remon
Journal:  Pharm Res       Date:  2000-04       Impact factor: 4.200

3.  What is the true solubility advantage for amorphous pharmaceuticals?

Authors:  B C Hancock; M Parks
Journal:  Pharm Res       Date:  2000-04       Impact factor: 4.200

4.  High critical temperature above T(g) may contribute to the stability of biological systems.

Authors:  J Buitink; I J van den Dries; F A Hoekstra; M Alberda; M A Hemminga
Journal:  Biophys J       Date:  2000-08       Impact factor: 4.033

5.  Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation.

Authors:  E D Breen; J G Curley; D E Overcashier; C C Hsu; S J Shire
Journal:  Pharm Res       Date:  2001-09       Impact factor: 4.200

6.  The application of near infrared spectroscopy and dynamic vapor sorption to quantify low amorphous contents of crystalline lactose.

Authors:  S E Hogan; G Buckton
Journal:  Pharm Res       Date:  2001-01       Impact factor: 4.200

7.  Detection of low levels of the amorphous phase in crystalline pharmaceutical materials by thermally stimulated current spectrometry.

Authors:  G M Venkatesh; M E Barnett; C Owusu-Fordjour; M Galop
Journal:  Pharm Res       Date:  2001-01       Impact factor: 4.200

8.  Ditosylate salt of itraconazole and dissolution enhancement using cyclodextrins.

Authors:  Neeraj Kumar; Gulshan Bansal; Sandeep Kumar; Asim Kumar Jana
Journal:  AAPS PharmSciTech       Date:  2012-06-06       Impact factor: 3.246

9.  Determination of glass transition temperature and in situ study of the plasticizing effect of water by inverse gas chromatography.

Authors:  Rahul Surana; Linda Randall; Abira Pyne; N Murti Vemuri; Raj Suryanarayanan
Journal:  Pharm Res       Date:  2003-10       Impact factor: 4.200

10.  Influence of alkali metal counterions on the glass transition temperature of amorphous indomethacin salts.

Authors:  Ping Tong; Lynne S Taylor; George Zografi
Journal:  Pharm Res       Date:  2002-05       Impact factor: 4.200
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