Literature DB >> 16906441

Cloned transgenic heart-healthy pork?

Randall S Prather1.   

Abstract

Here I comment on the production and uses of swine that express a humanized fat-1 gene. The gene product is a fatty acid desaturase that converts omega-6 fatty acids to omega-3 fatty acids. Omega-3 fatty acids have been implicated as being important for reproductive success, maintaining a healthy cardiovascular system, sustaining a functional immune system, and even preventing depression and cancer. The descendants of these hfat-1 transgenic swine will be very useful as models of the human condition, and if they are permitted to enter the food chain, they may improve human health.

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Year:  2006        PMID: 16906441     DOI: 10.1007/s11248-006-0022-3

Source DB:  PubMed          Journal:  Transgenic Res        ISSN: 0962-8819            Impact factor:   3.145


  13 in total

1.  Phenotyping of transgenic cloned piglets.

Authors:  D Bart Carter; Liangxue Lai; Kwang-Wook Park; Melissa Samuel; Jimmy C Lattimer; Kim R Jordan; D Mark Estes; Cynthia Besch-Williford; Randall S Prather
Journal:  Cloning Stem Cells       Date:  2002

2.  Cloned transgenic swine via in vitro production and cryopreservation.

Authors:  Rongfeng Li; Liangxue Lai; David Wax; Yanhong Hao; Clifton N Murphy; August Rieke; Melissa Samuel; Mike L Linville; Scott W Korte; Rhobert W Evans; James R Turk; Jing X Kang; William T Witt; Yifan Dai; Randall S Prather
Journal:  Biol Reprod       Date:  2006-05-03       Impact factor: 4.285

Review 3.  Nuclear remodeling and nuclear reprogramming for making transgenic pigs by nuclear transfer.

Authors:  Randall S Prather
Journal:  Adv Exp Med Biol       Date:  2007       Impact factor: 2.622

4.  Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis.

Authors:  J P Spychalla; A J Kinney; J Browse
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

5.  Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis.

Authors:  L Duret; D Mouchiroud
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

6.  Generation of cloned transgenic pigs rich in omega-3 fatty acids.

Authors:  Liangxue Lai; Jing X Kang; Rongfeng Li; Jingdong Wang; William T Witt; Hwan Yul Yong; Yanhong Hao; David M Wax; Clifton N Murphy; August Rieke; Melissa Samuel; Michael L Linville; Scott W Korte; Rhobert W Evans; Thomas E Starzl; Randall S Prather; Yifan Dai
Journal:  Nat Biotechnol       Date:  2006-03-26       Impact factor: 54.908

7.  Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

Authors:  Liangxue Lai; Donna Kolber-Simonds; Kwang-Wook Park; Hee-Tae Cheong; Julia L Greenstein; Gi-Sun Im; Melissa Samuel; Aaron Bonk; August Rieke; Billy N Day; Clifton N Murphy; David B Carter; Robert J Hawley; Randall S Prather
Journal:  Science       Date:  2002-01-03       Impact factor: 47.728

8.  Aberrant DNA methylation in porcine in vitro-, parthenogenetic-, and somatic cell nuclear transfer-produced blastocysts.

Authors:  Aaron J Bonk; Rongfeng Li; Liangxue Lai; Yanhong Hao; Zhonghua Liu; Melissa Samuel; Emily A Fergason; Kristin M Whitworth; Clifton N Murphy; Eric Antoniou; Randall S Prather
Journal:  Mol Reprod Dev       Date:  2008-02       Impact factor: 2.609

9.  Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.

Authors:  Donna Kolber-Simonds; Liangxue Lai; Steven R Watt; Maria Denaro; Scott Arn; Monica L Augenstein; Jeffery Betthauser; David B Carter; Julia L Greenstein; Yanhong Hao; Gi-Sun Im; Zhonghua Liu; Greg D Mell; Clifton N Murphy; Kwang-Wook Park; August Rieke; David J J Ryan; David H Sachs; Erik J Forsberg; Randall S Prather; Robert J Hawley
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

10.  Methylation profiling of CpG islands in human breast cancer cells.

Authors:  T H Huang; M R Perry; D E Laux
Journal:  Hum Mol Genet       Date:  1999-03       Impact factor: 6.150

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  3 in total

1.  The influence of n-3 PUFA supplements and n-3 PUFA enriched foods on the n-3 LC PUFA intake of Flemish women.

Authors:  Isabelle Sioen; Jolien Devroe; David Inghels; Ruth Terwecoren; Stefaan De Henauw
Journal:  Lipids       Date:  2010-03-18       Impact factor: 1.880

2.  Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos.

Authors:  Jianguo Zhao; Yanhong Hao; Jason W Ross; Lee D Spate; Eric M Walters; Melissa S Samuel; August Rieke; Clifton N Murphy; Randall S Prather
Journal:  Cell Reprogram       Date:  2010-02       Impact factor: 1.987

3.  Precision genetics for complex objectives in animal agriculture.

Authors:  S C Fahrenkrug; A Blake; D F Carlson; T Doran; A Van Eenennaam; D Faber; C Galli; Q Gao; P B Hackett; N Li; E A Maga; W M Muir; J D Murray; D Shi; R Stotish; E Sullivan; J F Taylor; M Walton; M Wheeler; B Whitelaw; B P Glenn
Journal:  J Anim Sci       Date:  2010-03-12       Impact factor: 3.159

  3 in total

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