Literature DB >> 11778012

Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

Liangxue Lai1, Donna Kolber-Simonds, Kwang-Wook Park, Hee-Tae Cheong, Julia L Greenstein, Gi-Sun Im, Melissa Samuel, Aaron Bonk, August Rieke, Billy N Day, Clifton N Murphy, David B Carter, Robert J Hawley, Randall S Prather.   

Abstract

The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes.

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Year:  2002        PMID： 11778012     DOI： 10.1126/science.1068228

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  337 in total

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Review 4.  Genetic modification of xenografts.

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Review 7.  CD47 in xenograft rejection and tolerance induction.

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Journal:  Xenotransplantation       Date:  2010 Jul-Aug       Impact factor: 3.907

Review 8.  Alternatives to unmodified human islets for transplantation.

Authors:  Alberto Hayek; Gillian M Beattie
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9.  Cloned ferrets produced by somatic cell nuclear transfer.

Authors:  Ziyi Li; Xingshen Sun; Juan Chen; Xiaoming Liu; Samantha M Wisely; Qi Zhou; Jean-Paul Renard; Gregory H Leno; John F Engelhardt
Journal:  Dev Biol       Date:  2006-04-03       Impact factor: 3.582

10.  Generation of mastitis resistance in cows by targeting human lysozyme gene to β-casein locus using zinc-finger nucleases.

Authors:  Xu Liu; Yongsheng Wang; Yuchen Tian; Yuan Yu; Mingqing Gao; Guangdong Hu; Feng Su; Shaohui Pan; Yan Luo; Zekun Guo; Fusheng Quan; Yong Zhang
Journal:  Proc Biol Sci       Date:  2014-02-19       Impact factor: 5.349
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