BACKGROUND: Quantitative CT shows promise as an outcome measure for cystic fibrosis (CF) lung disease in infancy, but must be accomplished at a dose as low as reasonably achievable. OBJECTIVE: To determine the feasibility of ultra-low-dose CT for quantitative measurements of airway dimensions. MATERIALS AND METHODS: Two juvenile pigs were anesthetized and their lungs scanned at 25 cm H(2)O face-mask pressure in apnoea using beam currents of 5, 10, 20, 40 and 100 mAs. The lumen diameters and wall thicknesses of matched airways (n=22) at each dose were measured by two observers using validated software. Measurement variability at each dose was compared to that at 100 mAs (reference dose) for large and small airways (lumen diameter <2.5 mm). RESULTS: Lowering CT dose (mAs) affected measurement variability for lumen diameter of small and large airways (P<0.001) and for wall thickness of small (P<0.001), but not large (P=0.63), airways. To obtain the same measurement variability at 5 mAs as at 100 mAs, four to six small airways or one to three large airways have to be measured and averaged. CONCLUSION: Quantitative airway measurements are feasible on images obtained at as low as 5 mAs, but more airways need to be measured to compensate for greater measurement variability.
BACKGROUND: Quantitative CT shows promise as an outcome measure for cystic fibrosis (CF) lung disease in infancy, but must be accomplished at a dose as low as reasonably achievable. OBJECTIVE: To determine the feasibility of ultra-low-dose CT for quantitative measurements of airway dimensions. MATERIALS AND METHODS: Two juvenile pigs were anesthetized and their lungs scanned at 25 cm H(2)O face-mask pressure in apnoea using beam currents of 5, 10, 20, 40 and 100 mAs. The lumen diameters and wall thicknesses of matched airways (n=22) at each dose were measured by two observers using validated software. Measurement variability at each dose was compared to that at 100 mAs (reference dose) for large and small airways (lumen diameter <2.5 mm). RESULTS: Lowering CT dose (mAs) affected measurement variability for lumen diameter of small and large airways (P<0.001) and for wall thickness of small (P<0.001), but not large (P=0.63), airways. To obtain the same measurement variability at 5 mAs as at 100 mAs, four to six small airways or one to three large airways have to be measured and averaged. CONCLUSION: Quantitative airway measurements are feasible on images obtained at as low as 5 mAs, but more airways need to be measured to compensate for greater measurement variability.
Authors: Pim A de Jong; Yasutaka Nakano; Wim C Hop; Frederick R Long; Harvey O Coxson; Peter D Paré; Harm A Tiddens Journal: Am J Respir Crit Care Med Date: 2005-04-14 Impact factor: 21.405
Authors: Alan S Brody; Harm A W M Tiddens; Robert G Castile; Harvey O Coxson; Pim A de Jong; Jonathan Goldin; Walter Huda; Frederick R Long; Michael McNitt-Gray; Michael Rock; Terry E Robinson; Scott D Sagel Journal: Am J Respir Crit Care Med Date: 2005-08-11 Impact factor: 21.405
Authors: Ricardo Holderbaum do Amaral; Carlos S Nin; Vinicius V S de Souza; Giordano R T Alves; Edson Marchiori; Klaus Irion; Gustavo S P Meirelles; Bruno Hochhegger Journal: Lung Date: 2017-03-28 Impact factor: 2.584
Authors: Jens Petersen; Mathilde M W Wille; Lars Lau Rakêt; Aasa Feragen; Jesper H Pedersen; Mads Nielsen; Asger Dirksen; Marleen de Bruijne Journal: Eur Radiol Date: 2014-06-06 Impact factor: 5.315