BACKGROUND: Reducing the dose for each CT scan is important for children with cystic fibrosis (CF). OBJECTIVE: To determine whether the number of CT images and therefore the dose per CT scan could be reduced without any significant loss of information in children with CF. MATERIALS AND METHODS: A cohort of children with CF was followed with biennial surveillance CT scans, obtained in inspiration after a voluntary breath-hold as 1-mm thick images at 10-mm intervals from lung apex to base. A random set of 20 baseline CT scans and 10 follow-up CT scans were blinded. Sets of every image (10-mm intervals), every second image (20-mm intervals), every third image (30-mm intervals) and a selection of three and five images were scored randomly using a published CT scoring system by one experienced observer. RESULTS: The 20 subjects were 10 years of age with a range of 3.7-17.6 years at baseline. Fewer CT images resulted in a significantly lower (less abnormal) CT score and the number of patients positive for abnormalities decreased subsequently. At intervals greater than 20 mm no significant change in CT score over 2 years could be detected, while the CT scores at 10-mm (P=0.02) and 20-mm (P=0.02) intervals worsened significantly. CONCLUSIONS: A reduction in the number of inspiratory CT images by increasing the interval between images to greater than 10 mm is not a valid option for radiation dose reduction in children with CF.
BACKGROUND: Reducing the dose for each CT scan is important for children with cystic fibrosis (CF). OBJECTIVE: To determine whether the number of CT images and therefore the dose per CT scan could be reduced without any significant loss of information in children with CF. MATERIALS AND METHODS: A cohort of children with CF was followed with biennial surveillance CT scans, obtained in inspiration after a voluntary breath-hold as 1-mm thick images at 10-mm intervals from lung apex to base. A random set of 20 baseline CT scans and 10 follow-up CT scans were blinded. Sets of every image (10-mm intervals), every second image (20-mm intervals), every third image (30-mm intervals) and a selection of three and five images were scored randomly using a published CT scoring system by one experienced observer. RESULTS: The 20 subjects were 10 years of age with a range of 3.7-17.6 years at baseline. Fewer CT images resulted in a significantly lower (less abnormal) CT score and the number of patients positive for abnormalities decreased subsequently. At intervals greater than 20 mm no significant change in CT score over 2 years could be detected, while the CT scores at 10-mm (P=0.02) and 20-mm (P=0.02) intervals worsened significantly. CONCLUSIONS: A reduction in the number of inspiratory CT images by increasing the interval between images to greater than 10 mm is not a valid option for radiation dose reduction in children with CF.
Authors: Anne-Sophie Bonnel; Samuel Moon-Ho Song; Krishnaveni Kesavarju; Manisha Newaskar; Craig J Paxton; Daniel A Bloch; Richard B Moss; Terry E Robinson Journal: Pediatr Pulmonol Date: 2004-11
Authors: Pim A de Jong; Yasutaka Nakano; Wim C Hop; Frederick R Long; Harvey O Coxson; Peter D Paré; Harm A Tiddens Journal: Am J Respir Crit Care Med Date: 2005-04-14 Impact factor: 21.405
Authors: Helena Ferris; Maria Twomey; Fiachra Moloney; Siobhan B O'Neill; Kevin Murphy; Owen J O'Connor; Michael Maher Journal: World J Radiol Date: 2016-04-28
Authors: Shannon J Simpson; Lauren S Mott; Charles R Esther; Stephen M Stick; Graham L Hall Journal: Expert Rev Respir Med Date: 2013-06 Impact factor: 3.772