Literature DB >> 16896851

Ethics and research in critical care.

Henry J Silverman1, Francois Lemaire.   

Abstract

BACKGROUND: The past few years have witnessed several controversies regarding the ethics of conducting research involving critically ill patients, and such research is ethically challenging. DISCUSSION: Research ethics is a changing field, one that is influenced by empirical data, contemporary events, and new ideas regarding aspects of clinical trial design and protection of human subjects. We describe recent thoughts regarding several aspects of research ethics in the critical care context.
CONCLUSION: The ability of the research community to conduct research ethically and to maintain public trust would benefit from heightened awareness to the principles and requirements that govern such research.

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Year:  2006        PMID: 16896851     DOI: 10.1007/s00134-006-0305-4

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN: 0342-4642            Impact factor:   17.440


  58 in total

1.  What makes clinical research ethical?

Authors:  E J Emanuel; D Wendler; C Grady
Journal:  JAMA       Date:  2000 May 24-31       Impact factor: 56.272

Review 2.  The ethical analysis of risk.

Authors:  C Weijer
Journal:  J Law Med Ethics       Date:  2000       Impact factor: 1.718

3.  Research involving cognitively impaired adults.

Authors:  Jason H T Karlawish
Journal:  N Engl J Med       Date:  2003-04-03       Impact factor: 91.245

4.  A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients.

Authors:  James Dean Sandham; Russell Douglas Hull; Rollin Frederick Brant; Linda Knox; Graham Frederick Pineo; Christopher J Doig; Denny P Laporta; Sidney Viner; Louise Passerini; Hugh Devitt; Ann Kirby; Michael Jacka
Journal:  N Engl J Med       Date:  2003-01-02       Impact factor: 91.245

5.  Are institutional review boards effective in safeguarding patients in intensive care units?

Authors:  F Lemaire; C Brun-Buisson
Journal:  Curr Opin Anaesthesiol       Date:  2000-04       Impact factor: 2.706

6.  Monitoring and ensuring safety during clinical research.

Authors:  M A Morse; R M Califf; J Sugarman
Journal:  JAMA       Date:  2001-03-07       Impact factor: 56.272

7.  False hopes and best data: consent to research and the therapeutic misconception.

Authors:  P S Appelbaum; L H Roth; C W Lidz; P Benson; W Winslade
Journal:  Hastings Cent Rep       Date:  1987-04       Impact factor: 2.683

8.  Lessons from everyday lives: a moral justification for acute care research.

Authors:  Andrew D McRae; Charles Weijer
Journal:  Crit Care Med       Date:  2002-05       Impact factor: 7.598

9.  A prospective, controlled trial of a protocol-based strategy to discontinue mechanical ventilation.

Authors:  Jerry A Krishnan; Dana Moore; Carey Robeson; Cynthia S Rand; Henry E Fessler
Journal:  Am J Respir Crit Care Med       Date:  2004-01-15       Impact factor: 21.405

10.  Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients.

Authors:  G Gutierrez; F Palizas; G Doglio; N Wainsztein; A Gallesio; J Pacin; A Dubin; E Schiavi; M Jorge; J Pusajo
Journal:  Lancet       Date:  1992-01-25       Impact factor: 79.321

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  8 in total

1.  A short goodbye...

Authors:  Laurent Brochard
Journal:  Intensive Care Med       Date:  2007-02-14       Impact factor: 17.440

2.  What's new in ethics of cardio-pulmonary resuscitation research: too little time and too many rules?

Authors:  Antoniu O Petriş; Diana C Cimpoeşu; Didona Ungureanu
Journal:  Intensive Care Med       Date:  2014-11-22       Impact factor: 17.440

3.  Consent for Acute Care Research and the Regulatory "Gray Zone".

Authors:  Laura M Beskow; Christopher J Lindsell; Todd W Rice
Journal:  Am J Bioeth       Date:  2020-05       Impact factor: 11.229

4.  Ability of family members to predict patient's consent to critical care research.

Authors:  Magali Ciroldi; Alain Cariou; Christophe Adrie; Djilali Annane; Vincent Castelain; Yves Cohen; Arnaud Delahaye; Luc Marie Joly; Richard Galliot; Maité Garrouste-Orgeas; Laurent Papazian; Fabrice Michel; Nancy Kenstish Barnes; Benoit Schlemmer; Frédéric Pochard; Elie Azoulay
Journal:  Intensive Care Med       Date:  2007-03-15       Impact factor: 17.440

5.  Informed consent in paediatric critical care research--a South African perspective.

Authors:  Brenda M Morrow; Andrew C Argent; Sharon Kling
Journal:  BMC Med Ethics       Date:  2015-09-09       Impact factor: 2.652

6.  Selection bias in clinical stroke trials depending on ability to consent.

Authors:  Benjamin Hotter; Lena Ulm; Sarah Hoffmann; Mira Katan; Joan Montaner; Alejandro Bustamante; Andreas Meisel
Journal:  BMC Neurol       Date:  2017-12-04       Impact factor: 2.474

7.  Ethical tensions in the informed consent process for randomized clinical trials in emergency obstetric and newborn care in low and middle-income countries.

Authors:  Dan K Kaye; Gershom Chongwe; Nelson K Sewankambo
Journal:  BMC Med Ethics       Date:  2019-04-27       Impact factor: 2.652

Review 8.  Clinical research without consent in adults in the emergency setting: a review of patient and public views.

Authors:  Jan Lecouturier; Helen Rodgers; Gary A Ford; Tim Rapley; Lynne Stobbart; Stephen J Louw; Madeleine J Murtagh
Journal:  BMC Med Ethics       Date:  2008-04-29       Impact factor: 2.652

  8 in total

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