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Literature DB >> 16892398

Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.

Sarva Jayaprakash¹, Yasuyoshi Iso, Baojie Wan, Scott G Franzblau, Alan P Kozikowski.

Abstract

Entities: Chemical Gene

Mesh：

Substances：

Year: 2006 PMID： 16892398 DOI： 10.1002/cmdc.200600010

Source DB: PubMed Journal: ChemMedChem ISSN： 1860-7179 Impact factor: 3.466

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14 in total

1. High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

Authors: Subramaniam Ananthan; Ellen R Faaleolea; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Barbara E Laughon; Joseph A Maddry; Alka Mehta; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Nice Shindo; Dustin N Showe; Melinda I Sosa; William J Suling; E Lucile White
Journal: Tuberculosis (Edinb) Date: 2009-09-15 Impact factor: 3.131

2. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.

Authors: Sang Hyun Cho; Saradee Warit; Baojie Wan; Chang Hwa Hwang; Guido F Pauli; Scott G Franzblau
Journal: Antimicrob Agents Chemother Date: 2007-01-08 Impact factor: 5.191

3. Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.

Authors: Wei Lv; Biplab Banerjee; Katrina L Molland; Mohamed N Seleem; Adil Ghafoor; Maha I Hamed; Baojie Wan; Scott G Franzblau; Andrew D Mesecar; Mark Cushman
Journal: Bioorg Med Chem Date: 2013-11-15 Impact factor: 3.641

Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.

1. High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.

2. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.

3. Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase.

4. Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents.

Review 5. Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

6. A novel quinoline derivative that inhibits mycobacterial FtsZ.

7. 6-Chloro-2-cyclo-propyl-4-(trifluoro-meth-yl)quinoline.

8. Nicotinaldehyde [2,8-bis-(trifluoro-meth-yl)quinolin-4-yl]hydrazone monohydrate.

9. 3,4-Dimeth-oxy-benzaldehyde [2,8-bis-(trifluoro-meth-yl)quinolin-4-yl]hydrazone.

10. (R,S)-(±)-1-(2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-yl)ethanone methanol monosolvate.