Literature DB >> 1688644

Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.

J A Piccirilli1, T Krauch, S E Moroney, S A Benner.   

Abstract

A new Watson-Crick base pair, with a hydrogen bonding pattern different from that in the A.T and G.C base pairs, is incorporated into duplex DNA and RNA by DNA and RNA polymerases and expands the genetic alphabet from 4 to 6 letters. This expansion could lead to RNAs with greater diversity in functional groups and greater catalytic potential.

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Year:  1990        PMID: 1688644     DOI: 10.1038/343033a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  122 in total

1.  Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides.

Authors:  Eric T. Kool
Journal:  Chem Rev       Date:  1997-08-05       Impact factor: 60.622

2.  Neighbouring bases in template influence base-pairing of isoguanine.

Authors:  Agnieszka M Maciejewska; Katarzyna D Lichota; Jarosław T Kuśmierek
Journal:  Biochem J       Date:  2003-02-01       Impact factor: 3.857

3.  Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils.

Authors:  M Takashima; T Furuta; H Hanai; H Sugimura; E Kaneko
Journal:  Gut       Date:  2001-06       Impact factor: 23.059

Review 4.  Why nature chose A, C, G and U/T: an error-coding perspective of nucleotide alphabet composition.

Authors:  Dónall A Mac Dónaill
Journal:  Orig Life Evol Biosph       Date:  2003-10       Impact factor: 1.950

Review 5.  The case for an error minimizing standard genetic code.

Authors:  Stephen J Freeland; Tao Wu; Nick Keulmann
Journal:  Orig Life Evol Biosph       Date:  2003-10       Impact factor: 1.950

6.  Optimal alphabets for an RNA world.

Authors:  Paul P Gardner; Barbara R Holland; Vincent Moulton; Mike Hendy; David Penny
Journal:  Proc Biol Sci       Date:  2003-06-07       Impact factor: 5.349

7.  Enzymatic repair of an expanded genetic information system.

Authors:  Michael J Moser; James R Prudent
Journal:  Nucleic Acids Res       Date:  2003-09-01       Impact factor: 16.971

8.  What is the optimum size for the genetic alphabet?

Authors:  E Szathmáry
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

9.  The cold origin of life: B. Implications based on pyrimidines and purines produced from frozen ammonium cyanide solutions.

Authors:  Shin Miyakawa; H James Cleaves; Stanley L Miller
Journal:  Orig Life Evol Biosph       Date:  2002-06       Impact factor: 1.950

10.  Enzymatic incorporation of emissive pyrimidine ribonucleotides.

Authors:  Seergazhi G Srivatsan; Yitzhak Tor
Journal:  Chem Asian J       Date:  2009-03-02
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