Literature DB >> 1688629

Location of a highly conserved neutralizing epitope in the F glycoprotein of human respiratory syncytial virus.

J A López1, C Peñas, B García-Barreno, J A Melero, A Portela.   

Abstract

Trypsin digestion of the purified F protein from human respiratory syncytial virus (Long strain) generated a set of fragments in the amino-terminal third of the F1 subunit which contained the epitope 47F involved in neutralization. Sequencing of five escape mutant viruses selected with monoclonal antibody 47F allowed us to map precisely two amino acid residues (262 and 268) of the F1 subunit which are essential for the integrity of this important epitope. The results are discussed in terms of the mechanisms involved in virus neutralization and the design of potential synthetic vaccines.

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Year:  1990        PMID： 1688629      PMCID： PMC249192     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

1.  Marked differences in the antigenic structure of human respiratory syncytial virus F and G glycoproteins.

Authors:  B García-Barreno; C Palomo; C Peñas; T Delgado; P Perez-Breña; J A Melero
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

2.  Identification of a synthetic peptide as part of a major neutralization epitope of respiratory syncytial virus.

Authors:  M Trudel; F Nadon; C Seguin; G Dionne; M Lacroix
Journal:  J Gen Virol       Date:  1987-09       Impact factor: 3.891

3.  Nucleotide sequence of the fusion and phosphoprotein genes of human respiratory syncytial (RS) virus Long strain: evidence of subtype genetic heterogeneity.

Authors:  J A López; N Villanueva; J A Melero; A Portela
Journal:  Virus Res       Date:  1988-05       Impact factor: 3.303

4.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

5.  An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine.

Authors:  A Z Kapikian; R H Mitchell; R M Chanock; R A Shvedoff; C E Stewart
Journal:  Am J Epidemiol       Date:  1969-04       Impact factor: 4.897

6.  Effects of the modification of transfer buffer composition and the renaturation of proteins in gels on the recognition of proteins on Western blots by monoclonal antibodies.

Authors:  S D Dunn
Journal:  Anal Biochem       Date:  1986-08-15       Impact factor: 3.365

7.  Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants.

Authors:  P F Wright; T Shinozaki; W Fleet; S H Sell; J Thompson; D T Karzon
Journal:  J Pediatr       Date:  1976-06       Impact factor: 4.406

8.  Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit.

Authors:  N Elango; M Satake; J E Coligan; E Norrby; E Camargo; S Venkatesan
Journal:  Nucleic Acids Res       Date:  1985-03-11       Impact factor: 16.971

9.  Protein-blotting on Polybrene-coated glass-fiber sheets. A basis for acid hydrolysis and gas-phase sequencing of picomole quantities of protein previously separated on sodium dodecyl sulfate/polyacrylamide gel.

Authors:  J Vandekerckhove; G Bauw; M Puype; J Van Damme; M Van Montagu
Journal:  Eur J Biochem       Date:  1985-10-01

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  24 in total

1.  Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion.

Authors:  L González-Reyes; M B Ruiz-Argüello; B García-Barreno; L Calder; J A López; J P Albar; J J Skehel; D C Wiley; J A Melero
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-07       Impact factor: 11.205

2.  Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein.

Authors:  Margarita Magro; David Andreu; Paulino Gómez-Puertas; José A Melero; Concepción Palomo
Journal:  J Virol       Date:  2010-06-09       Impact factor: 5.103

3.  Premature stop codons in the G glycoprotein of human respiratory syncytial viruses resistant to neutralization by monoclonal antibodies.

Authors:  P Rueda; T Delgado; A Portela; J A Melero; B García-Barreno
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

4.  Conservation of epitopes recognized by monoclonal antibodies against the separated subunits of influenza hemagglutinin among type A viruses of the same and different subtypes.

Authors:  A Sanchez-Fauquier; M Guillen; J Martin; A P Kendal; J A Melero
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

5.  Induction of a neutralizing immune response to human respiratory syncytial virus with anti-idiotypic antibodies.

Authors:  C Palomo; J P Albar; B García-Barreno; J A Melero
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

6.  Antigenic structure of human respiratory syncytial virus fusion glycoprotein.

Authors:  J A López; R Bustos; C Orvell; M Berois; J Arbiza; B García-Barreno; J A Melero
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

7.  Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab.

Authors:  Qing Zhu; Josie M McAuliffe; Nita K Patel; Frances J Palmer-Hill; Chin-fen Yang; Brandon Liang; Lan Su; Wei Zhu; Leslie Wachter; Susan Wilson; Randall S MacGill; Subramaniam Krishnan; Michael P McCarthy; Genevieve A Losonsky; JoAnn A Suzich
Journal:  J Infect Dis       Date:  2011-01-05       Impact factor: 5.226

8.  Amino acid variation within the fusion protein of respiratory syncytial virus subtype A and B strains during annual epidemics in South Africa.

Authors:  Elizabeth Agenbach; Caroline T Tiemessen; Marietjie Venter
Journal:  Virus Genes       Date:  2005-03       Impact factor: 2.332

9.  Antigenic analysis of the F protein of the bovine respiratory syncytial virus: identification of two distinct antigenic sites involved in fusion inhibition.

Authors:  J P Matheise; K Walravens; A Collard; P Coppe; J J Letesson
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

10.  Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.

Authors:  Jason S McLellan; Man Chen; Sherman Leung; Kevin W Graepel; Xiulian Du; Yongping Yang; Tongqing Zhou; Ulrich Baxa; Etsuko Yasuda; Tim Beaumont; Azad Kumar; Kayvon Modjarrad; Zizheng Zheng; Min Zhao; Ningshao Xia; Peter D Kwong; Barney S Graham
Journal:  Science       Date:  2013-04-25       Impact factor: 47.728
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