Literature DB >> 16870780

Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.

Dóra Szabó1, Fernanda Silveira, Andrea M Hujer, Robert A Bonomo, Kristine M Hujer, Jane W Marsh, Christopher R Bethel, Yohei Doi, Kathleen Deeley, David L Paterson.   

Abstract

We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

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Year:  2006        PMID： 16870780      PMCID： PMC1538668          DOI： 10.1128/AAC.01591-05

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.

Authors:  George A Jacoby; Debra M Mills; Nancy Chow
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

3.  SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae.

Authors:  Dóra Szabó; Robert A Bonomo; Fernanda Silveira; A William Pasculle; Carla Baxter; Peter K Linden; Andrea M Hujer; Kristine M Hujer; Kathleen Deeley; David L Paterson
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

4.  Type I beta-lactamases of gram-negative bacteria: interactions with beta-lactam antibiotics.

Authors:  C C Sanders; W E Sanders
Journal:  J Infect Dis       Date:  1986-11       Impact factor: 5.226

5.  Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem.

Authors:  E H Lee; M H Nicolas; M D Kitzis; G Pialoux; E Collatz; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

6.  Diffusion of beta-lactam antibiotics into proteoliposomes reconstituted with outer membranes of isogenic imipenem-susceptible and -resistant strains of Enterobacter cloacae.

Authors:  E H Lee; E Collatz; J Trias; L Gutmann
Journal:  J Gen Microbiol       Date:  1992-11

7.  Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases.

Authors:  David L Paterson; Kristine M Hujer; Andrea M Hujer; Bethany Yeiser; Michael D Bonomo; Louis B Rice; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

8.  Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.

Authors:  K Bush; S K Tanaka; D P Bonner; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

9.  RamA is an alternate activator of the multidrug resistance cascade in Enterobacter aerogenes.

Authors:  Renaud Chollet; Jacqueline Chevalier; Claude Bollet; Jean-Marie Pages; Anne Davin-Regli
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

10.  Analyses of ampC gene expression in Serratia marcescens reveal new regulatory properties.

Authors:  Steven D Mahlen; Stacey S Morrow; Baha Abdalhamid; Nancy D Hanson
Journal:  J Antimicrob Chemother       Date:  2003-02-25       Impact factor: 5.790
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  29 in total

1.  Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae.

Authors:  Ghady Haidar; Cornelius J Clancy; Liang Chen; Palash Samanta; Ryan K Shields; Barry N Kreiswirth; M Hong Nguyen
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

Review 2.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 3.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

4.  Characterization of ertapenem-resistant Enterobacter cloacae in a Taiwanese university hospital.

Authors:  Fu-Chen Yang; Jing-Jou Yan; Kuei-Hsiang Hung; Jiunn-Jong Wu
Journal:  J Clin Microbiol       Date:  2011-11-30       Impact factor: 5.948

5.  Association of Novel Nonsynonymous Single Nucleotide Polymorphisms in ampD with Cephalosporin Resistance and Phylogenetic Variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae Isolates That Are Highly Resistant to Carbapenems.

Authors:  Baharak Babouee Flury; Matthew J Ellington; Katie L Hopkins; Jane F Turton; Michel Doumith; Richard Loy; Peter Staves; Vladimira Hinic; Reno Frei; Neil Woodford
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

6.  Prevalence and characteristics of ertapenem-nonsusceptible Escherichia coli in a Taiwanese university hospital, 1999 to 2007.

Authors:  J J Yan; J J Wu; C C Lee; W C Ko; F C Yang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-08-11       Impact factor: 3.267

7.  Structural Basis of Reduced Susceptibility to Ceftazidime-Avibactam and Cefiderocol in Enterobacter cloacae Due to AmpC R2 Loop Deletion.

Authors:  Akito Kawai; Christi L McElheny; Alina Iovleva; Ellen G Kline; Nicolas Sluis-Cremer; Ryan K Shields; Yohei Doi
Journal:  Antimicrob Agents Chemother       Date:  2020-06-23       Impact factor: 5.191

8.  Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016.

Authors:  Fiona Senchyna; Rajiv L Gaur; Johanna Sandlund; Cynthia Truong; Guillaume Tremintin; Dietmar Kültz; Carlos A Gomez; Fiona B Tamburini; Tessa Andermann; Ami Bhatt; Isabella Tickler; Nancy Watz; Indre Budvytiene; Gongyi Shi; Fred C Tenover; Niaz Banaei
Journal:  Diagn Microbiol Infect Dis       Date:  2018-10-13       Impact factor: 2.803

9.  Detection of plasmid-mediated IMP-1 metallo-beta-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate.

Authors:  Li-rong Chen; Hong-wei Zhou; Jia-chang Cai; Rong Zhang; Gong-xiang Chen
Journal:  J Zhejiang Univ Sci B       Date:  2009-05       Impact factor: 3.066

10.  Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan.

Authors:  S-S Jean; P-R Hsueh; W-S Lee; H-T Chang; M-Y Chou; I-S Chen; J-H Wang; C-F Lin; J-M Shyr; W-C Ko; J-J Wu; Y-C Liu; W-K Huang; L-J Teng; C-Y Liu
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2008-08-21       Impact factor: 3.267
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