Literature DB >> 16856936

Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters.

Oded Lewinson1, Julia Adler, Nadejda Sigal, Eitan Bibi.   

Abstract

Multidrug (Mdr) transport is an obstacle to the successful treatment of cancer and infectious diseases, and it is mediated by Mdr transporters that recognize and export an unusually broad spectrum of chemically dissimilar toxic compounds. Therefore, in addition to its clinical significance, the Mdr transport phenomenon presents intriguing and challenging mechanistic queries. Recent studies of secondary Mdr transporters of the major facilitator superfamily (MFS) have revealed that they are promiscuous not only regarding their substrate recognition profile, but also with respect to matters of energy utilization, electrical and chemical flexibility in the Mdr recognition pocket, and surprisingly, also in their physiological functions.

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Year:  2006        PMID： 16856936     DOI： 10.1111/j.1365-2958.2006.05254.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  28 in total

1.  No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA.

Authors:  Nadejda Sigal; Shahar Molshanski-Mor; Eitan Bibi
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

2.  The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.

Authors:  Nadejda Sigal; Nir Fluman; Shira Siemion; Eitan Bibi
Journal:  J Biol Chem       Date:  2009-01-07       Impact factor: 5.157

3.  Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR.

Authors:  Sharrol Bachas; Christopher Eginton; Drew Gunio; Herschel Wade
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

4.  A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.

Authors:  Jan H Reiling; Clary B Clish; Jan E Carette; Malini Varadarajan; Thijn R Brummelkamp; David M Sabatini
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-15       Impact factor: 11.205

5.  Simulations of substrate transport in the multidrug transporter EmrD.

Authors:  Joseph Baker; Stephen H Wright; Florence Tama
Journal:  Proteins       Date:  2012-03-20

Review 6.  Energy metabolism and drug efflux in Mycobacterium tuberculosis.

Authors:  Philippa A Black; Robin M Warren; Gail E Louw; Paul D van Helden; Thomas C Victor; Bavesh D Kana
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

7.  Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress.

Authors:  Millie Kaplan Zeevi; Nirit S Shafir; Shira Shaham; Sivan Friedman; Nadejda Sigal; Ran Nir Paz; Ivo G Boneca; Anat A Herskovits
Journal:  J Bacteriol       Date:  2013-09-20       Impact factor: 3.490

8.  The plant-associated bacterium Stenotrophomonas rhizophila expresses a new enzyme for the synthesis of the compatible solute glucosylglycerol.

Authors:  Martin Hagemann; Kathrin Ribbeck-Busch; Stephan Klähn; Dirk Hasse; Robert Steinbruch; Gabriele Berg
Journal:  J Bacteriol       Date:  2008-06-27       Impact factor: 3.490

9.  Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis.

Authors:  Breck A Duerkop; John Varga; Josephine R Chandler; Snow Brook Peterson; Jake P Herman; Mair E A Churchill; Matthew R Parsek; William C Nierman; E Peter Greenberg
Journal:  J Bacteriol       Date:  2009-04-17       Impact factor: 3.490

10.  Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transporters.

Authors:  Jouhyun Jeon; Jae-Seong Yang; Sanguk Kim
Journal:  PLoS Comput Biol       Date:  2009-10-02       Impact factor: 4.475
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