Literature DB >> 10735877

A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins.

D L Jack1, M L Storms, J H Tchieu, I T Paulsen, M H Saier.   

Abstract

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

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Year:  2000        PMID： 10735877      PMCID： PMC111283          DOI： 10.1128/JB.182.8.2311-2313.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  The multidrug efflux protein NorM is a prototype of a new family of transporters.

Authors:  M H Brown; I T Paulsen; R A Skurray
Journal:  Mol Microbiol       Date:  1999-01       Impact factor: 3.501

Review 2.  Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria.

Authors:  M H Saier; I T Paulsen; M K Sliwinski; S S Pao; R A Skurray; H Nikaido
Journal:  FASEB J       Date:  1998-03       Impact factor: 5.191

Review 3.  A bacterial model system for understanding multi-drug resistance.

Authors:  M H Saier; I T Paulsen; A Matin
Journal:  Microb Drug Resist       Date:  1997       Impact factor: 3.431

4.  Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli.

Authors:  H Yerushalmi; M Lebendiker; S Schuldiner
Journal:  J Biol Chem       Date:  1996-12-06       Impact factor: 5.157

5.  Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.

Authors:  L M Guzman; D Belin; M J Carson; J Beckwith
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

6.  Scanning cysteine accessibility of EmrE, an H+-coupled multidrug transporter from Escherichia coli, reveals a hydrophobic pathway for solutes.

Authors:  S S Mordoch; D Granot; M Lebendiker; S Schuldiner
Journal:  J Biol Chem       Date:  1999-07-02       Impact factor: 5.157

7.  Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities.

Authors:  I T Paulsen; M K Sliwinski; M H Saier
Journal:  J Mol Biol       Date:  1998-04-03       Impact factor: 5.469

8.  EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents.

Authors:  H Yerushalmi; M Lebendiker; S Schuldiner
Journal:  J Biol Chem       Date:  1995-03-24       Impact factor: 5.157

9.  NMR investigation of the multidrug transporter EmrE, an integral membrane protein.

Authors:  M Schwaiger; M Lebendiker; H Yerushalmi; M Coles; A Gröger; C Schwarz; S Schuldiner; H Kessler
Journal:  Eur J Biochem       Date:  1998-06-15

10.  Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.

Authors:  B A Mitchell; I T Paulsen; M H Brown; R A Skurray
Journal:  J Biol Chem       Date:  1999-02-05       Impact factor: 5.157
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  35 in total

Review 1.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

2.  Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454.

Authors:  S Magnet; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

3.  Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistance.

Authors:  M Ito; A A Guffanti; W Wang; T A Krulwich
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

4.  The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions.

Authors:  Oded Lewinson; Julia Adler; Gerrit J Poelarends; Piotr Mazurkiewicz; Arnold J M Driessen; Eitan Bibi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-10       Impact factor: 11.205

Review 5.  Structure and function of efflux pumps that confer resistance to drugs.

Authors:  M Ines Borges-Walmsley; Kenneth S McKeegan; Adrian R Walmsley
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

6.  New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.

Authors:  Jeffrey E Barrick; Keith A Corbino; Wade C Winkler; Ali Nahvi; Maumita Mandal; Jennifer Collins; Mark Lee; Adam Roth; Narasimhan Sudarsan; Inbal Jona; J Kenneth Wickiser; Ronald R Breaker
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-19       Impact factor: 11.205

7.  Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli.

Authors:  Che Ma; Geoffrey Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-17       Impact factor: 11.205

Review 8.  Investigating transport proteins by solid state NMR.

Authors:  Daniel Basting; Ines Lehner; Mark Lorch; Clemens Glaubitz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-02-28       Impact factor: 3.000

9.  No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA.

Authors:  Nadejda Sigal; Shahar Molshanski-Mor; Eitan Bibi
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

10.  Genetic characterization of plasmid-associated benzalkonium chloride resistance determinants in a Listeria monocytogenes strain from the 1998-1999 outbreak.

Authors:  Driss Elhanafi; Vikrant Dutta; Sophia Kathariou
Journal:  Appl Environ Microbiol       Date:  2010-10-22       Impact factor: 4.792
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