Literature DB >> 1685477

Linkage mapping of highly informative DNA polymorphisms within the human interferon-alpha receptor gene on chromosome 21.

M G McInnis1, G Lutfalla, S Slaugenhaupt, M B Petersen, G Uze, A Chakravarti, S E Antonarakis.   

Abstract

Two polymorphic loci within the interferon-alpha receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (theta = 0.02, zeta = 36.76) and D21S17 (theta = 0.02, Zeta = 21.76) with chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21.

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Year:  1991        PMID： 1685477     DOI： 10.1016/0888-7543(91)90064-l

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  8 in total

1.  Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.

Authors:  M B Peterson; M Frantzen; S E Antonarakis; A C Warren; C Van Broeckhoven; A Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

2.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

3.  No evidence for a paternal interchromosomal effect from analysis of the origin of nondisjunction in Down syndrome patients with concomitant familial chromosome rearrangements.

Authors:  A A Schinzel; P A Adelsberger; F Binkert; S Basaran; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

4.  Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

Authors:  G Lutfalla; M G McInnis; S E Antonarakis; G Uzé
Journal:  J Mol Evol       Date:  1995-09       Impact factor: 2.395

5.  Unusual genotypes in the COL6A1 gene in parents of children with trisomy 21 and major congenital heart defects.

Authors:  G E Davies; C M Howard; M J Farrer; M M Coleman; L M Cullen; R Williamson; R K Wyse; A M Kessling
Journal:  Hum Genet       Date:  1994-04       Impact factor: 4.132

6.  Meiotic crossing-over in nondisjoined chromosomes of children with trisomy 21 and a congenital heart defect.

Authors:  C M Howard; G E Davies; M J Farrer; L M Cullen; M M Coleman; R Williamson; R K Wyse; R Palmer; A M Kessling
Journal:  Am J Hum Genet       Date:  1993-08       Impact factor: 11.025

7.  No significant effect of monosomy for distal 21q22.3 on the Down syndrome phenotype in "mirror" duplications of chromosome 21.

Authors:  C Pangalos; D Théophile; P M Sinet; A Marks; D Stamboulieh-Abazis; Z Chettouh; M Prieur; C Verellen; M O Rethoré; J Lejeune
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

8.  Cytogenetic, FISH and DNA studies in 11 individuals from a family with two siblings with dup(21q) Down syndrome.

Authors:  O Bartsch; U König; M B Petersen; H Poulsen; M Mikkelsen; F Palau; F Prieto; E Schwinger
Journal:  Hum Genet       Date:  1993-09       Impact factor: 4.132
  8 in total

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