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Literature DB >> 7563119

Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

G Lutfalla¹, M G McInnis, S E Antonarakis, G Uzé.

Abstract

The cytokine receptor family consists of a growing number of structurally and evolutionarily related transmembrane receptors. CRFB4 and IFNAR are two of the most similar members of this family. They are encoded by two neighboring genes on both human chromosome 21 and murine chromosome 16. The sequence of the human CRFB4 gene was determined from the first exon to the last intron. The nature of the repetitive sequences present in the introns was analyzed and compared with those present in the human IFNAR gene. This analysis leads to considerations of the antiquity of the duplication that gave rise to both genes from a common ancestor. A pseudogene for USF has been identified in the IFNAR gene and a new definition for the repetitive sequence MER37 is proposed. The polymorphism associated with two CA repeats present in the CRFB4 gene is described.

Entities: Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7563119 DOI： 10.1007/BF00186545

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

22 in total

1. Structural symmetry of the extracellular domain of the cytokine/growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis.

Authors: E Thoreau; B Petridou; P A Kelly; J Djiane; J P Mornon
Journal: FEBS Lett Date: 1991-04-22 Impact factor: 4.124

5. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

Authors: G Lutfalla; S J Holland; E Cinato; D Monneron; J Reboul; N C Rogers; J M Smith; G R Stark; K Gardiner; K E Mogensen
Journal: EMBO J Date: 1995-10-16 Impact factor: 11.598

5 in total

Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

1. Structural symmetry of the extracellular domain of the cytokine/growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis.

2. Amplification dynamics of human-specific (HS) Alu family members.

3. Structural design and molecular evolution of a cytokine receptor superfamily.

4. Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

5. Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region.

6. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.

7. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

8. The structure of the human interferon alpha/beta receptor gene.

9. Identification of a new, abundant superfamily of mammalian LTR-transposons.

10. The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome.

1. Members of the pogo superfamily of DNA-mediated transposons in the human genome.

2. Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression.

3. Tiggers and DNA transposon fossils in the human genome.

4. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor.

5. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.