Literature DB >> 1684709

Predominance of distinct viral genotypes in brain and lymph node compartments of HIV-1-infected individuals.

S Haggerty1, M Stevenson.   

Abstract

A modified polymerase chain reaction protocol was used to amplify the entire envelope-coding region of HIV-1 directly from brain and lymph node tissue obtained at autopsy from three HIV-1-infected individuals. Molecular analysis of amplified DNA by digestion with 18 restriction endonucleases, singly and in combination, revealed different HIV-1 genotypes in the brain and lymph node compartments in each of the three individuals. This anatomic compartmentalization of HIV-1 populations may reflect different viral genomic sequences that determine tropism or differences in host immune selection pressures in the brain and lymphoid compartments that drive the emergence of distinct viral populations.

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Year:  1991        PMID： 1684709      PMCID： PMC9513715          DOI： 10.1089/vim.1991.4.123

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.175


  38 in total

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2.  In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV).

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Authors:  L A Lasky; G Nakamura; D H Smith; C Fennie; C Shimasaki; E Patzer; P Berman; T Gregory; D J Capon
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4.  Biological and molecular characterization of human immunodeficiency virus (HIV-1BR) from the brain of a patient with progressive dementia.

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5.  Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages.

Authors:  D J Eilbott; N Peress; H Burger; D LaNeve; J Orenstein; H E Gendelman; R Seidman; B Weiser
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

6.  Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS.

Authors:  S Gartner; P Markovits; D M Markovitz; R F Betts; M Popovic
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8.  Molecular cloning and characterization of a German HIV-1 isolate.

Authors:  U Sauermann; J Schneider; J Mous; U Brunckhorst; I Schedel; K D Jentsch; G Hunsmann
Journal:  AIDS Res Hum Retroviruses       Date:  1990-06       Impact factor: 2.205

9.  Persistent human immunodeficiency virus type 1 infection of monoblastoid cells leads to accumulation of self-integrated viral DNA and to production of defective virions.

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Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

10.  HIV-1 replication is controlled at the level of T cell activation and proviral integration.

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  27 in total

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2.  In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues.

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Review 3.  Antiretroviral therapy for HIV infection. A knowledge-based approach to drug selection and use.

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5.  Cerebrospinal fluid pleocytosis as a predictive factor for CSF and plasma HIV RNA discordance and escape.

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Review 6.  HIV evolution and escape.

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7.  In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop.

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8.  Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection.

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Review 9.  The meningeal lymphatic system: a route for HIV brain migration?

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Review 10.  Pathogenesis of human immunodeficiency virus infection.

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