| Literature DB >> 17060974 |
Douglas D Richman1, Susan J Little, Davey M Smith, Terri Wrin, Christos Petropoulos, Joseph K Wong.
Abstract
Human immunodeficiency virus (HIV) exemplifies the principles of Darwinian evolution with a telescoped chronology. Because of its high mutation rate and remarkably high rates of replication, evolution can be appreciated over periods of days in contrast to the durations conceived of by Darwin. Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described.Entities:
Mesh:
Substances:
Year: 2004 PMID: 17060974 PMCID: PMC2263778
Source DB: PubMed Journal: Trans Am Clin Climatol Assoc ISSN: 0065-7778