Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.

The peripheral H1-inhibiting effects of cetirizine 10 mg and ebastine 10 mg were compared at the skin level after single oral administration. The study was performed in 9 healthy subjects under double-blind randomized crossover conditions. Both drugs were significantly effective up to 24 h. The suppressive effect of cetirizine was significantly more rapid and more marked.

RCT Entities:   Population Interventions Outcomes