Literature DB >> 16836383

A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.

Bruce Z Lu1, Wenyi Zhao, Han-Xun Wei, Marine Dufour, Vittorio Farina, Chris H Senanayake.   

Abstract

[Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

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Year:  2006        PMID： 16836383     DOI： 10.1021/ol061136q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Preparation of 2,3-Disubstituted Indoles by Sequential Larock Heteroannulation and Silicon-Based Cross-Coupling Reactions.

Authors:  Scott E Denmark; John D Baird
Journal:  Tetrahedron       Date:  2009-04-18       Impact factor: 2.457

2.  An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions.

Authors:  Yu Chen; Nataliya A Markina; Richard C Larock
Journal:  Tetrahedron       Date:  2009-10-31       Impact factor: 2.457

3.  Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.

Authors:  John M Knapp; Jie S Zhu; Dean J Tantillo; Mark J Kurth
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-24       Impact factor: 15.336

4.  A facile, mild and efficient one-pot synthesis of 2-substituted indole derivatives catalyzed by Pd(PPh3)2Cl2.

Authors:  Hossien A Oskooie; Majid M Heravi; Farahnaz K Behbahani
Journal:  Molecules       Date:  2007-06-19       Impact factor: 4.411

5.  A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.

Authors:  Pei-Yuan Yao; Yu Zhang; Richard P Hsung; Kang Zhao
Journal:  Org Lett       Date:  2008-08-28       Impact factor: 6.005

6.  Amines as key building blocks in Pd-assisted multicomponent processes.

Authors:  Didier Bouyssi; Nuno Monteiro; Geneviève Balme
Journal:  Beilstein J Org Chem       Date:  2011-10-10       Impact factor: 2.883

7.  Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium.

Authors:  Sofia Siciliano; Elena Cini; Maurizio Taddei; Giorgia Vinciarelli
Journal:  Molecules       Date:  2021-06-26       Impact factor: 4.411
  7 in total

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