Literature DB >> 18754591

A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.

Pei-Yuan Yao1, Yu Zhang, Richard P Hsung, Kang Zhao.   

Abstract

A sequential <span class="Chemical">metal-catalyzed C-N bond formation employing <class="Chemical">span class="Chemical">ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.

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Year:  2008        PMID： 18754591      PMCID： PMC2662137          DOI： 10.1021/ol801711p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  51 in total

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5.  Copper-catalyzed coupling of amides and carbamates with vinyl halides.

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8.  Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.

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9.  Copper-mediated N-alkynylation of carbamates, ureas, and sulfonamides. A general method for the synthesis of ynamides.

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  8 in total

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Journal:  Org Lett       Date:  2009-02-19       Impact factor: 6.005

5.  A Rhodium(I)-Xylyl-BINAP Catalyzed Asymmetric Ynamide-[2 + 2 + 2] Cycloaddition in the Synthesis of Optically Enriched N,O-Biaryls.

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Journal:  Tetrahedron       Date:  2009-06-27       Impact factor: 2.457

6.  Synthesis of poly-functionalized benzofurans via one-pot domino oxidation/[3+2] cyclization reactions of a hydroquinone ester and ynamides.

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7.  Regio- and stereoselective carbometallation reactions of N-alkynylamides and sulfonamides.

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8.  Palladium-catalyzed C-N and C-O bond formation of N-substituted 4-bromo-7-azaindoles with amides, amines, amino acid esters and phenols.

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  8 in total

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