BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. METHODS: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. RESULTS: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). CONCLUSIONS: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.
BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. METHODS: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. RESULTS: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). CONCLUSIONS: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.
Authors: Mariet Allen; Claire Cox; Olivia Belbin; Li Ma; Gina D Bisceglio; Samantha L Wilcox; Chanley C Howell; Talisha A Hunter; Oliver Culley; Louise P Walker; Minerva M Carrasquillo; Dennis W Dickson; Ronald C Petersen; Neill R Graff-Radford; Steven G Younkin; Nilüfer Ertekin-Taner Journal: Neurobiol Aging Date: 2010-09-23 Impact factor: 4.673
Authors: Joseph H Lee; Rong Cheng; Ekaterina Rogaeva; Yan Meng; Yaakov Stern; Vincent Santana; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux Journal: Neurogenetics Date: 2008-03-14 Impact factor: 2.660
Authors: Mariet Allen; Fanggeng Zou; High Seng Chai; Curtis S Younkin; Richard Miles; Asha A Nair; Julia E Crook; V Shane Pankratz; Minerva M Carrasquillo; Christopher N Rowley; Thuy Nguyen; Li Ma; Kimberly G Malphrus; Gina Bisceglio; Alexandra I Ortolaza; Ryan Palusak; Sumit Middha; Sooraj Maharjan; Constantin Georgescu; Debra Schultz; Fariborz Rakhshan; Christopher P Kolbert; Jin Jen; Sigrid B Sando; Jan O Aasly; Maria Barcikowska; Ryan J Uitti; Zbigniew K Wszolek; Owen A Ross; Ronald C Petersen; Neill R Graff-Radford; Dennis W Dickson; Steven G Younkin; Nilüfer Ertekin-Taner Journal: Mol Neurodegener Date: 2012-04-11 Impact factor: 14.195