Literature DB >> 17659183

Genetics of Alzheimer's disease: a centennial review.

Nilüfer Ertekin-Taner1.   

Abstract

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1, PSEN2) and one late-onset AD susceptibility gene, apolipoprotein E (APOE), exist with ample biologic, genetic, and epidemiologic data. Evidence suggests a significant genetic component underlying AD that is not explained by the known genetic risk factors. This article summarizes the evidence for the genetic component in AD and the identification of the early-onset familial AD genes and APOE, and examines the current state of knowledge about additional AD susceptibility loci and alleles. The future directions for genetic research in AD as a common and complex condition are also discussed.

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Year:  2007        PMID： 17659183      PMCID： PMC2735049          DOI： 10.1016/j.ncl.2007.03.009

Source DB:  PubMed          Journal:  Neurol Clin        ISSN： 0733-8619            Impact factor:   3.806


  173 in total

Review 1.  Epidemiology of neurodegeneration.

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Journal:  Annu Rev Neurosci       Date:  2003-01-24       Impact factor: 12.449

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Journal:  Genet Epidemiol       Date:  2004-07       Impact factor: 2.135

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Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

4.  Purification and cloning of amyloid precursor protein beta-secretase from human brain.

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Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

Review 5.  Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease.

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Journal:  Neurobiol Aging       Date:  2005-10-27       Impact factor: 4.673

6.  ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.

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Journal:  Neurobiol Dis       Date:  2005-02       Impact factor: 5.996

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10.  Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

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Journal:  JAMA       Date:  1997 Oct 22-29       Impact factor: 56.272
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  89 in total

1.  Association and heterogeneity at the GAPDH locus in Alzheimer's disease.

Authors:  Mariet Allen; Claire Cox; Olivia Belbin; Li Ma; Gina D Bisceglio; Samantha L Wilcox; Chanley C Howell; Talisha A Hunter; Oliver Culley; Louise P Walker; Minerva M Carrasquillo; Dennis W Dickson; Ronald C Petersen; Neill R Graff-Radford; Steven G Younkin; Nilüfer Ertekin-Taner
Journal:  Neurobiol Aging       Date:  2010-09-23       Impact factor: 4.673

Review 2.  Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.

Authors:  Puneet Talwar; Juhi Sinha; Sandeep Grover; Chitra Rawat; Suman Kushwaha; Rachna Agarwal; Vibha Taneja; Ritushree Kukreti
Journal:  Mol Neurobiol       Date:  2015-09-09       Impact factor: 5.590

3.  Accuracy of reported family history and effectiveness of medical record requests in genetic counseling for Alzheimer disease.

Authors:  Emily L R Alexander; Rachel K Butler; Colleen Guimond; Blair Butler; A Dessa Sadovnick
Journal:  J Genet Couns       Date:  2010-09-28       Impact factor: 2.537

4.  Genetic susceptibility for Alzheimer disease neuritic plaque pathology.

Authors:  Joshua M Shulman; Kewei Chen; Brendan T Keenan; Lori B Chibnik; Adam Fleisher; Pradeep Thiyyagura; Auttawut Roontiva; Cristin McCabe; Nikolaos A Patsopoulos; Jason J Corneveaux; Lei Yu; Matthew J Huentelman; Denis A Evans; Julie A Schneider; Eric M Reiman; Philip L De Jager; David A Bennett
Journal:  JAMA Neurol       Date:  2013-09-01       Impact factor: 18.302

Review 5.  Gender differences in factors associated with delirium severity in older adults with dementia.

Authors:  Ann M Kolanowski; Nikki L Hill; Esra Kurum; Donna M Fick; Andrea M Yevchak; Paula Mulhall; Linda Clare; Michael Valenzuela
Journal:  Arch Psychiatr Nurs       Date:  2014-02-05       Impact factor: 2.218

6.  Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

Authors:  Steven G Potkin; Guia Guffanti; Anita Lakatos; Jessica A Turner; Frithjof Kruggel; James H Fallon; Andrew J Saykin; Alessandro Orro; Sara Lupoli; Erika Salvi; Michael Weiner; Fabio Macciardi
Journal:  PLoS One       Date:  2009-08-07       Impact factor: 3.240

7.  Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.

Authors:  Miguel A Gama Sosa; Rita De Gasperi; Anne B Rocher; Athena Ching-Jung Wang; William G M Janssen; Tony Flores; Gissel M Perez; James Schmeidler; Dara L Dickstein; Patrick R Hof; Gregory A Elder
Journal:  Am J Pathol       Date:  2009-12-11       Impact factor: 4.307

8.  Geographical differences in the occurrence of Alzheimer's disease mortality: United States versus Puerto Rico.

Authors:  Raul Figueroa; Kyle Steenland; Jessica R MacNeil; Allan I Levey; Irving E Vega
Journal:  Am J Alzheimers Dis Other Demen       Date:  2008 Oct-Nov       Impact factor: 2.035

Review 9.  Genetic susceptibility testing for neurodegenerative diseases: ethical and practice issues.

Authors:  J Scott Roberts; Wendy R Uhlmann
Journal:  Prog Neurobiol       Date:  2013-04-09       Impact factor: 11.685

10.  Association between the RAGE G82S polymorphism and Alzheimer's disease.

Authors:  Keshen Li; Dawei Dai; Bin Zhao; Lifen Yao; Songpo Yao; Binyou Wang; Ze Yang
Journal:  J Neural Transm (Vienna)       Date:  2009-11-10       Impact factor: 3.575
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