Literature DB >> 18800015

Proteomics of human neurodegenerative diseases.

Jing Zhang1, C Dirk Keene, Catherine Pan, Kathleen S Montine, Thomas J Montine.   

Abstract

The technology, experimental approaches, and bioinformatics that support proteomic research are evolving rapidly. The application of these new capabilities to the study of neurodegenerative diseases is providing insight into the biochemical pathogenesis of neurodegeneration as well as fueling major efforts in biomarker discovery. Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases.

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Year:  2008        PMID: 18800015      PMCID: PMC2710115          DOI: 10.1097/NEN.0b013e318187a832

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN: 0022-3069            Impact factor:   3.685


  99 in total

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