Literature DB >> 16831105

Error thresholds in genetic algorithms.

Gabriela Ochoa1.   

Abstract

The error threshold of replication is an important notion in the quasispecies evolution model; it is a critical mutation rate (error rate) beyond which structures obtained by an evolutionary process are destroyed more frequently than selection can reproduce them. With mutation rates above this critical value, an error catastrophe occurs and the genomic information is irretrievably lost. Therefore, studying the factors that alter this magnitude has important implications in the study of evolution. Here we use a genetic algorithm, instead of the quasispecies model, as the underlying model of evolution, and explore whether the phenomenon of error thresholds is found on finite populations of bit strings evolving on complex landscapes. Our empirical results verify the occurrence of error thresholds in genetic algorithms. In this way, this notion is brought from molecular evolution to evolutionary computation. We also study the effect of modifying the most prominent evolutionary parameters on the magnitude of this critical value, and found that error thresholds depend mainly on the selection pressure and genotype length.

Entities:  

Mesh:

Year:  2006        PMID: 16831105     DOI: 10.1162/evco.2006.14.2.157

Source DB:  PubMed          Journal:  Evol Comput        ISSN: 1063-6560            Impact factor:   3.277


  9 in total

Review 1.  Viral quasispecies evolution.

Authors:  Esteban Domingo; Julie Sheldon; Celia Perales
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

2.  Average Fitness Differences on NK Landscapes.

Authors:  Wim Hordijk; Stuart A Kauffman; Peter F Stadler
Journal:  Theory Biosci       Date:  2019-06-18       Impact factor: 1.919

3.  Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.

Authors:  Celia Perales; Michel Henry; Esteban Domingo; Simon Wain-Hobson; Jean-Pierre Vartanian
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

4.  Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach.

Authors:  Josep Sardanyés; Tomás Alarcón
Journal:  Sci Rep       Date:  2018-01-18       Impact factor: 4.379

5.  A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.

Authors:  Rubén Agudo; Cristina Ferrer-Orta; Armando Arias; Ignacio de la Higuera; Celia Perales; Rosa Pérez-Luque; Nuria Verdaguer; Esteban Domingo
Journal:  PLoS Pathog       Date:  2010-08-26       Impact factor: 6.823

6.  Critical mutation rate has an exponential dependence on population size in haploid and diploid populations.

Authors:  Elizabeth Aston; Alastair Channon; Charles Day; Christopher G Knight
Journal:  PLoS One       Date:  2013-12-27       Impact factor: 3.240

7.  Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover.

Authors:  Elizabeth Aston; Alastair Channon; Roman V Belavkin; Danna R Gifford; Rok Krašovec; Christopher G Knight
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379

8.  Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.

Authors:  Celia Perales; Rubén Agudo; Hector Tejero; Susanna C Manrubia; Esteban Domingo
Journal:  PLoS Pathog       Date:  2009-11-13       Impact factor: 6.823

9.  Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.

Authors:  Ana M Ortega-Prieto; Julie Sheldon; Ana Grande-Pérez; Héctor Tejero; Josep Gregori; Josep Quer; Juan I Esteban; Esteban Domingo; Celia Perales
Journal:  PLoS One       Date:  2013-08-16       Impact factor: 3.240

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.