Literature DB >> 16829980

The biogenesis and regulation of telomerase holoenzymes.

Kathleen Collins1.   

Abstract

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase, telomerase, has an important role in maintaining this equilibrium. Insights that have been gained into the cellular pathways for biogenesis and regulation of telomerase ribonucleoproteins raise new questions, particularly concerning the dynamic nature of this unique polymerase.

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Year:  2006        PMID： 16829980      PMCID： PMC2915765          DOI： 10.1038/nrm1961

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  159 in total

1.  Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase.

Authors:  C D Hardy; C S Schultz; K Collins
Journal:  J Biol Chem       Date:  2000-11-28       Impact factor: 5.157

2.  The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo.

Authors:  L P Ford; J W Shay; W E Wright
Journal:  RNA       Date:  2001-08       Impact factor: 4.942

3.  Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

Authors:  H L Forsythe; J L Jarvis; J W Turner; L W Elmore; S E Holt
Journal:  J Biol Chem       Date:  2001-03-23       Impact factor: 5.157

4.  Human telomerase contains two cooperating telomerase RNA molecules.

Authors:  C Wenz; B Enenkel; M Amacker; C Kelleher; K Damm; J Lingner
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

Review 5.  Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again.

Authors:  Nicholas R Forsyth; Woodring E Wright; Jerry W Shay
Journal:  Differentiation       Date:  2002-01       Impact factor: 3.880

6.  Tetrahymena proteins p80 and p95 are not core telomerase components.

Authors:  D X Mason; C Autexier; C W Greider
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-09       Impact factor: 11.205

7.  The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.

Authors:  T Vulliamy; A Marrone; F Goldman; A Dearlove; M Bessler; P J Mason; I Dokal
Journal:  Nature       Date:  2001-09-27       Impact factor: 49.962

8.  Functional multimerization of the human telomerase reverse transcriptase.

Authors:  T L Beattie; W Zhou; M O Robinson; L Harrington
Journal:  Mol Cell Biol       Date:  2001-09       Impact factor: 4.272

9.  The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.

Authors:  X Z Zhou; K P Lu
Journal:  Cell       Date:  2001-11-02       Impact factor: 41.582

10.  N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo.

Authors:  B N Armbruster; S S Banik; C Guo; A C Smith; C M Counter
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272
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  135 in total

Review 1.  Telomerase: an RNP enzyme synthesizes DNA.

Authors:  Elizabeth H Blackburn; Kathleen Collins
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-05-01       Impact factor: 10.005

2.  Targeted 2'-O methylation at a nucleotide within the pseudoknot of telomerase RNA reduces telomerase activity in vivo.

Authors:  Chao Huang; Yi-Tao Yu
Journal:  Mol Cell Biol       Date:  2010-07-20       Impact factor: 4.272

Review 3.  Roles of DEAD-box proteins in RNA and RNP Folding.

Authors:  Cynthia Pan; Rick Russell
Journal:  RNA Biol       Date:  2010-11-01       Impact factor: 4.652

4.  Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA.

Authors:  Qi Zhang; Nak-Kyoon Kim; Robert D Peterson; Zhonghua Wang; Juli Feigon
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-21       Impact factor: 11.205

5.  The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation.

Authors:  Alec N Sexton; Kathleen Collins
Journal:  Mol Cell Biol       Date:  2010-12-13       Impact factor: 4.272

6.  Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α.

Authors:  Jia Sun; Yuting Yang; Ke Wan; Ninghui Mao; Tai-Yuan Yu; Yi-Chien Lin; Diane C DeZwaan; Brian C Freeman; Jing-Jer Lin; Neal F Lue; Ming Lei
Journal:  Cell Res       Date:  2010-09-28       Impact factor: 25.617

7.  A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.

Authors:  Andrew S Venteicher; Eladio B Abreu; Zhaojing Meng; Kelly E McCann; Rebecca M Terns; Timothy D Veenstra; Michael P Terns; Steven E Artandi
Journal:  Science       Date:  2009-01-30       Impact factor: 47.728

Review 8.  xRRM: a new class of RRM found in the telomerase La family protein p65.

Authors:  Mahavir Singh; Charles P Choi; Juli Feigon
Journal:  RNA Biol       Date:  2013-01-17       Impact factor: 4.652

Review 9.  Structured non-coding RNAs and the RNP Renaissance.

Authors:  J Robert Hogg; Kathleen Collins
Journal:  Curr Opin Chem Biol       Date:  2008-10-23       Impact factor: 8.822

10.  Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.

Authors:  Eun Young Yu; Wei-Feng Yen; Olga Steinberg-Neifach; Neal F Lue
Journal:  Mol Cell Biol       Date:  2009-12-14       Impact factor: 4.272
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