Literature DB >> 16828752

Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells.

Bo Li1, Wei-Dong Zhao, Zhi-Min Tan, Wen-Gang Fang, Li Zhu, Yu-Hua Chen.   

Abstract

Small cell lung cancer (SCLC) cells migration across human brain microvascular endothelial cells (HBMECs) is an essential step of brain metastases. Here we investigated signalling pathways in HBMECs contributing to the process. Inhibition of endothelial Rho kinase (ROCK) with Y27632 and overexpression of ROCK dominant-negative mutant prevented SCLC cells, NCI-H209, transendothelial migration and the concomitant changes of tight junction. Conversely, inhibition of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) had no effects. Furthermore, endothelial RhoA protein was activated during NCI-H209 cells transendothelial migration. Rho/ROCK participated in NCI-H209 cells transendothelial migration through regulating actin cytoskeleton reorganization. These results suggested that Rho/ROCK was required for SCLC cells transendothelial migration.

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Year:  2006        PMID： 16828752     DOI： 10.1016/j.febslet.2006.06.056

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  62 in total

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